Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
Reads0
Chats0
TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
More filters
Journal ArticleDOI
Stroke prevention: modifying risk factors
TL;DR: The impact of modifiable traditional vascular risk factors on ischemic stroke, interventions for stroke prevention, and evidence for early treatment of risk factors where available are discussed, as well as areas of research progress.
Journal ArticleDOI
Alternate-day dosing of aspirin in atrial fibrillation
TL;DR: In this trial low-dose aspirin given on alternate days seemed to be an efficient intervention in preventing major cardiovascular events and Regarding strokes, however, aspirin was less efficient.
Journal ArticleDOI
Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects.
TL;DR: The role of the oral anticoagulation in both prevention and treatment of various types of thrombo‐occlusive and ‐embolic disease is evaluated to better understand the pathophysiology of those diseases as well as to better characterize the pre‐thrombotic state.
Journal ArticleDOI
Bleeding in patients receiving vitamin K antagonists who would have been excluded from trials on which the indication for anticoagulation was based
Marcel Levi,G. Kees Hovingh,Suzanne C. Cannegieter,Marinus Vermeulen,Harry R. Büller,Frits R. Rosendaal +5 more
TL;DR: Whether patients and controls would have been eligible for the clinical trials on which their indication for anticoagulation was based was analyzed, and the risk of hemorrhage associated with exclusion criteria as applied in those trials was estimated.
Journal ArticleDOI
The electrophysiologic basis, surgical development and clinical results of the maze procedure for atrial flutter and atrial fibrillation
James L. Cox,John P. Boineau,Richard B. Schuessler,Kathryn M. Kater,T. Bruce Ferguson,Michael E. Cain,Bruce D. Lindsay,Joseph M. Smith,Peter B. Corr,Charles B. Hogue,Demetrious G. Lappas +10 more
TL;DR: A surgical procedure that appears to cure the arrhythmia and the surgical results have been excellent, indicating that sophisticated electrophysiologic mapping systems are unnecessary and that the results are not surgeonspecific.
References
More filters
Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Related Papers (5)
Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
Mg Ceravolo,Leandro Provinciali +1 more