Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Patent
Methods of epicardial ablation for creating a lesion around the pulmonary veins
TL;DR: In this article, a plurality of probes are provided with each probe configured for introduction into the chest for engaging the heart, each probe includes an elongated shaft and the elongated ablating surface of each probe are configured to ablate a portion of the heart.
Journal ArticleDOI
Left atrial spontaneous echo contrast: a clinical and echocardiographic analysis.
TL;DR: Left atrial spontaneous echo contrast is a common finding in patients undergoing transesophageal echocardiography, associated with conditions favoring stasis of left atrial blood, and a marker of previous thromboembolism in patients with nonvalvular atrial fibrillation and those with mitral stenosis or mitral valve replacement.
Journal ArticleDOI
Warfarin Use Associates with Increased Risk for Stroke in Hemodialysis Patients with Atrial Fibrillation
TL;DR: Warfarin use among patients with both ESRD and atrial fibrillation associates with an increased risk for stroke, and the risk is greatest in warfarin users who do not receive in-facility INR monitoring.
Journal ArticleDOI
Hospitalized patients with atrial fibrillation and a high risk of stroke are not being provided with adequate anticoagulation.
TL;DR: It was shown that risk stratification, the guidepost for treatment in international guidelines, had little effect on warfarin use, and that age >80 years and AF classification (permanent/persistent) are factors that influence warFarin use.
Journal ArticleDOI
Outcome parameters for trials in atrial fibrillation: executive summary.
Paulus Kirchhof,Angelo Auricchio,Jeroen J. Bax,Harry J.G.M. Crijns,John Camm,Hans-Christoph Diener,Andreas Goette,Gerd Hindricks,Stefan H. Hohnloser,Lukas Kappenberger,Karl Heinz Kuck,Gregory Y.H. Lip,Bertil Olsson,Thomas Meinertz,Silvia G. Priori,Ursula Ravens,Gerhard Steinbeck,Elisabeth Svernhage,Jan Tijssen,Alphons Vincent,Günter Breithardt +20 more
TL;DR: An expert consensus of required outcome parameters in seven relevant outcome domains, namely death, stroke, symptoms and quality of life, rhythm, left ventricular function, cost, and emerging outcome parameters, are described.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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