Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Bleeding risk of antiplatelet drugs compared with oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-analysis.
M Melkonian,Witold Jarzebowski,Eric Pautas,Virginie Siguret,Joël Belmin,Carmelo Lafuente-Lafuente +5 more
TL;DR: Risks and benefits of antiplatelet drugs should be carefully weighted in elderly patients, and the risk of major bleeding was similar with antiplatelets and with anticoagulant drugs.
Journal ArticleDOI
Oral Anticoagulants to Prevent Stroke in Nonvalvular Atrial Fibrillation in Patients With CKD Stage 5D: An NKF-KDOQI Controversies Report
Vinod Bansal,Charles A. Herzog,Mark J. Sarnak,Michael J. Choi,Ravindra L. Mehta,Bernard G. Jaar,Michael V. Rocco,Holly Kramer +7 more
TL;DR: Data from randomized clinical trials are urgently needed to determine the benefits and risks of oral anticoagulant use for stroke prevention in the setting of AF among patients with CKD-5D.
Journal ArticleDOI
Oral anticoagulation in nonvalvular atrial fibrillation.
B. G. Koefoed,P. Petersen +1 more
TL;DR: More trials have now confirmed that oral anticoagulation at INR‐values below 2.0 is not effective for prevention of thromboembolic events in patients at a high risk of stroke.
Journal ArticleDOI
Lone atrial fibrillation: epidemiology and natural history.
TL;DR: In this paper, the authors focus on the heterogeneity that characterizes the syndrome of non-rheumatic or non-valvular atrial fibrillation, which is associated with a considerable independent increase in mortality rates and a 4-fold to 5-fold increase in the incidence of stroke.
Journal ArticleDOI
Should we just let the anticoagulation service do it? The conundrum of anticoagulation for atrial fibrillation.
TL;DR: Although not assessed in the Cleveland study, it is impor tant to consider not only how frequently warfarin is used in patients with atrial fibrillation but also how well it is used.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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