Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Randomized Trials of Warfarin for Atrial Fibrillation
TL;DR: The article by Ezekowitz et al. in this issue of the Journal 1 marks the completion of a remarkable set of five contemporaneous randomized trials testing the efficacy of warfarin in the prevention of infectious disease.
Journal ArticleDOI
Influence of percutaneous mitral commissurotomy on left atrial spontaneous contrast of mitral stenosis
Bertrand Cormier,Alec Vahanian,Bernard lung,Jean Marc Porte,Eric Dadez,Arnaud Lazarus,Charles Starkman,Jean Acar +7 more
TL;DR: To assess the influence of percutaneous mitral commissurotomy on left atrial spontaneous echo contrast of mitral stenosis, transesophageal echocardiography was performed before and 24 to 48 hours after the procedure, and 6 months later in 82 patients.
Journal ArticleDOI
Mixed treatment comparison meta-analysis of aspirin, warfarin, and new anticoagulants for stroke prevention in patients with nonvalvular atrial fibrillation.
TL;DR: This mixed treatment comparison meta-analysis found similarity between warfarin and the new anticoagulants with the exception of one comparison, in which warfar in was associated with more non-major bleeding than apixaban.
Journal ArticleDOI
Atrial high-rate episodes: prevalence, stroke risk, implications for management, and clinical gaps in evidence
Emanuele Bertaglia,Benjamin F. Blank,Carina Blomström-Lundqvist,Axel Brandes,Axel Brandes,Nuno Cabanelas,G-Andrei Dan,Wolfgang Dichtl,Andreas Goette,Joris R. de Groot,Andrzej Lubiński,Eloi Marijon,Béla Merkely,Lluís Mont,Christopher Piorkowski,Andrea Sarkozy,Neil Sulke,Panos E. Vardas,Vasil Velchev,Dan Wichterle,Paulus Kirchhof +20 more
TL;DR: A comprehensive, tabulated review of published literature on the prevalence of atrial high-rate episodes and their impact on risk of stroke in patients with AHRE and in patients without AHRE, found that oral anticoagulation has the potential to reduce stroke risk but is associated with a rate of major bleeding of 2%/year.
Journal ArticleDOI
Anticoagulation for atrial fibrillation
TL;DR: Future research is needed to specify the risk of stroke and hemorrhage among patients with AF better, particularly among older individuals, to optimize use of antithrombotic agents, and to define the role of recently developed antithromabotic drugs and invasive nondrug approaches.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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