Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Evaluation of clinical treatment of atrial fibrillation associated with rheumatic mitral valve disease by radiofrequency ablation.
TL;DR: The addition of the radiofrequency ablation maze procedure to mitral valve replacement is safe and effective in the treatment of atrial fibrillation associated with rheumatic mitral valves disease.
How to compare the costs and benefits: evaluation of the economic evidence
TL;DR: This handbook explains the usefulness and relevance of economics in the function of clinical practice guidelines and provides information on how to assess the cost-effectiveness and the proposed guidelines, and then discusses whether the chosen alternative is economically feasible.
Journal ArticleDOI
High Concentration of Thrombomodulin in Plasma Is Associated With Hemorrhage A Prospective Study in Patients Receiving Long-term Anticoagulant Treatment
TL;DR: It is found that the numbers both of serious hemorrhages and of total hemorrhages were significantly associated with increased levels of thrombomodulin, which is related to the risk of hemorrhage in patients treated with oral anticoagulants.
Journal ArticleDOI
Antithrombotic treatment and atrial fibrillation.
TL;DR: The message for doctors considering primary prophylaxis with warfarin in people with atrial fibrillation is therefore clear: if you wish to do more good than harm choose patients at sufficiently high thromboembolic risk.
Journal ArticleDOI
Long-term results of percutaneous aspiration embolectomy.
TL;DR: PAE is highly effective in the treatment of embolic occlusions of the lower leg arteries and should be considered as an alternative to Fogarty balloon embolectomy.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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