Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Adverse Effects of Coumarin Anticoagulants
Graham F. Pineo,Russell D. Hull +1 more
TL;DR: The more widespread use of the International Normalised Ratio for the control of anticoagulants will undoubtedly further decrease the risk of haemorrhage, but new innovations such as the use of ultra low-dose warfarin or newer techniques for the continued monitoring of oral anticoageulants are still required, particularly as the indications for oral antICOagulant continue to expand.
MONITORIZAÇÃO DA TERAPÊUTICA COM ANTICOAGULANTES ORAIS Consulta de Anticoagulação vs Médico Assistente
Rui Barreira,João Carlos Ribeiro,Margarida Farinha,Rosa Martins,Iolanda Rodrigues,Francisco Crespo,S. Teotónio +6 more
TL;DR: A terapeutica com anticoagulantes orais necessita of ser monitorizada as discussed by the authors, e na maioria dos cases realizada quer pelo medico assistente do doente, quer atraves de consultas ou clinicas antico-agulacao.
Journal ArticleDOI
Antithrombotic Therapy After Acute Ischemic Stroke in Patients With Atrial Fibrillation
Emer R. McGrath,M K Kapral,Jiming Fang,John W. Eikelboom,Aengus O Conghaile,Michelle Canavan,Martin O'Donnell +6 more
TL;DR: Contrary to current guidelines, 30% of patients with atrial fibrillation and recent IS are not prescribed any OAC therapy on discharge, whereas a further 30% are prescribed combination OAC and antiplatelet therapy.
Journal ArticleDOI
Relationship Between CHADS2 Score and Ischemic Stroke During Rhythm Control Therapy for Paroxysmal Atrial Fibrillation
Takashi Komatsu,Hideaki Tachibana,Yoshihiro Sato,M. Ozawa,Fusanori Kunugida,Makoto Orii,Motoyuki Nakamura +6 more
TL;DR: In Japanese patients with paroxysmal AF, the CHADS2 score is useful for predicting the risk of ischemic stroke, and anticoagulant therapy is needed to prevent isChemic stroke in patients withParoxys mal AF, especially those who have a CHADS1 score of 2 or more.
Journal ArticleDOI
Anticoagulation in the elderly.
TL;DR: Emphasis has been placed on maximizing the benefit and reducing the risk of anticoagulation in the rapidly expanding group of elderly patients aged >/=75 who are at the greatest risk of stroke and are likely to benefit the most from antithrombotic therapy.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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