Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Atrial fibrillation: advances and perspectives
A. John Camm,Irina Savelieva +1 more
TL;DR: Prevention of AF is an attractive possibility that will rely on general prevention of cardiac disease, identification of those at risk of AF, and the development of specific therapeutic strategies to prevent the evolution of an electrophysiological milieu that will support the arrhythmia.
Journal ArticleDOI
Outcomes of Long-Term Anticoagulation in Frail Elderly Patients with Atrial Fibrillation
TL;DR: The patients in this study had a rate of bleeds higher than in reported clinical trials, and their older age and greater co-morbidity were the likely causes of this difference.
Journal ArticleDOI
Therapy in cerebrovascular disease: current status and future directions.
TL;DR: The aim is to assess the current status and future directions of therapy in cerebrovascular disease and to determine the next steps in treatment.
Journal ArticleDOI
Minimizing the risk of hemorrhagic stroke during anticoagulant therapy for atrial fibrillation
Giacomo Zoppellaro,Serena Granziera,Seena Padayattil Jose,Gentian Denas,A. Bracco,Sabino Iliceto,Vittorio Pengo +6 more
TL;DR: Direct oral anticoagulants (DOAC) are associated with lower risk of hemorrhagic stroke than VKA, however, periodic hepatic and renal checks as well as careful evaluation of time adherence are necessary to reduce the risk of bleeding.
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Survey of Botulinum Toxin Injections in Anticoagulated Patients: Korean Physiatrists' Preference in Controlling Anticoagulation Profile Prior to Intramuscular Injection
Yongjun Jang,Geun-Young Park,Jihye Park,Asayeon Choi,Soo Yeon Kim,Chris Boulias,Chetan P. Phadke,Farooq Ismail,Sun Im +8 more
TL;DR: The survey shows a wide range of practices among many Korean physiatrists; they tend to avoid botulinum toxin injection in anticoagulated patients and are uncertain about how to approach these patients.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
Mg Ceravolo,Leandro Provinciali +1 more