Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
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Journal ArticleDOI
Trends in utilization of antithrombotic therapy in patients with atrial fibrillation before stroke onset in a community-based study, from 1985 through 1997. From scientific evidence to practice.
Guy-Victor Osseby,Isabelle Benatru,Daniela Sochurkova,Renaud Urbinelli,Salah-Eddine Megherbi,G. Couvreur,Thibault Moreau,Jean-Eric Wolf,Maurice Giroud +8 more
TL;DR: Clinical practice is inconsistent with the guidelines resulting from therapeutic trials because close to 50% of patients with atrial fibrillation experiencing an acute stroke or TIA received antithrombotic treatment, and it appears that the most significant change occurred within the period 1992-1994.
Journal ArticleDOI
How Well Does the Target INR Level Maintain in Warfarin-Treated Patients with Non-ValvularAtrial Fibrillation?
TL;DR: It was showed that it was not enough to maintain INR values within the target range in warfarin-treated patients with NVAF even at a tertiary hospital, suggesting noncompliance is an important problem which interferes with maintaining target INR range.
Journal ArticleDOI
Acute and chronic management of atrial fibrillation in patients with late-stage CKD.
TL;DR: A 76-year-old white woman with stage 5 chronic kidney isease (CKD) receiving hemodialysis for the past 3 months evelops atrial fibrillation with a ventricular rate of 170 eats/min, precipitating left-sided heart failure and pulmoary congestion as discussed by the authors.
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Bringing the Benefits of Anticoagulation Management Services to the Community: Alberta Program May Serve as a Model of Care
Tammy J. Bungard,Stephen L. Archer,Peter Hamilton,Bruce Ritchie,Wayne Tymchak,Ross T. Tsuyuki +5 more
TL;DR: This project created community-based, pharmacist-managed anticoagulation management services for patients requiring warfarin therapy and may serve as a model for other health regions and other chronic diseases.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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