Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Hemorrhagic complications of oral anticoagulant therapy.
TL;DR: The risk for anticoagulant-related bleeding cannot be considered in isolation and the potential benefits need to be weighed carefully in each individual patient, irregardless of age.
Journal ArticleDOI
Trends in risk of stroke in patients with a hospital diagnosis of nonvalvular atrial fibrillation: National Cohort Study in Denmark, 1980-2002.
TL;DR: A modest decrease in risk of stroke in subject with atrial fibrillation in Denmark during calendar years 1980–2002 is observed, however, the authors could not control for any changes in diagnostic performance, admission practice, and medical management of patients with atrium fibrillillation.
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A plea for a clinical trial of anticoagulation in dilated cardiomyopathy
TL;DR: Important differences exist between thrombus formation in myocardial infarction and dilated cardiomyopathy and possibilities for assessing and safely reducing thromboembolic events originating from the myopathic ventricle are discussed.
Journal ArticleDOI
Combined antiplatelet therapy in atrial fibrillation: Review of the literature and future research avenues
TL;DR: The present knowledge and potential future research avenues for the role of antiplatelet therapy in AF as an alternative to anticoagulation with warfarin for prevention of AF‐associated stroke are reviewed.
Journal ArticleDOI
A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents
Stephanie Joppa,Justin D. Salciccioli,Jill Adamski,Salma I. Patel,Waldemar E. Wysokinski,Robert D. McBane,Farah Al-Saffar,Heidi Esser,Fadi Shamoun +8 more
TL;DR: The use of oral anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation and the treatment and prevention of venous thrombosis, has become more prevalent in recent years but many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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