Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Radiofrequency Catheter Ablation of the Atria Reduces Inducibility and Duration of Atrial Fibrillation in Dogs
TL;DR: In this paper, radiofrequency catheter ablation of the atria in an open-chest canine model was used to prevent sustained atrial fibrillation (AF) with burst stimulation or premature atrial pacing.
Journal ArticleDOI
Low-Dose Aspirin for Prevention of Stroke in Low-Risk Patients With Atrial Fibrillation: Japan Atrial Fibrillation Stroke Trial
Hiroshi Sato,Kinji Ishikawa,Akira Kitabatake,Satoshi Ogawa,Yukio Maruyama,Yoshiyuki Yokota,Takaya Fukuyama,Yoshinori Doi,Seibu Mochizuki,Tohru Izumi,Noboru Takekoshi,Kiyoshi Yoshida,Katsuhiko Hiramori,Hideki Origasa,Shinichiro Uchiyama,Masayasu Matsumoto,Takenori Yamaguchi,Masatsugu Hori +17 more
TL;DR: For prevention of stroke in patients with NVAF, aspirin at 150 to 200 mg per day does not seem to be either effective or safe, and further prospective studies are needed to determine the best preventive therapy for cerebrovascular events in Japanese patients withNVAF.
Journal ArticleDOI
Chronic atrial fibrillation - Success of serial cardioversion therapy and safety of oral anticoagulation
I. C. Van Gelder,Harry J.G.M. Crijns,Robert G. Tieleman,Johan Brügemann,PJ de Kam,A. T. M. Gosselink,Freek W.A. Verheugt,Kong I. Lie +7 more
TL;DR: Many patients with chronic atrial fibrillation failed to respond to the serial electrical cardioversion strategy, but in younger patients with a fair exercise tolerance and a duration of atrialfibrillation shorter than 36 months, this approach may be worthwhile.
Journal ArticleDOI
The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials.
TL;DR: An overview of the gastrointestinal toxicity of aspirin, its most serious complication after intracerebral haemorrhage, is presented and the efficacy of low doses of aspirin (75 mg daily) are demonstrated.
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Physician Attitudes About Anticoagulation for Nonvalvular Atrial Fibrillation in the Elderly
TL;DR: Anticoagulant therapy may be less often and less intensively used for elderly patients with nonvalvular atrial fibrillation.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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