Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Implementation of antithrombotic management in atrial fibrillation.
TL;DR: If improved antithrombotic management of atrial fibrillation were extrapolated to all hospital patients in the United Kingdom, approximately 1400 strokes/year could be avoided.
Journal ArticleDOI
Lone atrial fibrillation and stroke.
TL;DR: Patients from the Lausanne Stroke Registry, who had first‐ever ischemic stroke and lone atrial fibrillation, with a standard protocol of investigations including brain CT, and non‐invasive cardiac and arterial tests suggested that cardioembolism was the cause of stroke, though echocardiographic evidence for an atrial thrombus was uncommon.
Journal ArticleDOI
Stroke subtypes and their possible implication in stroke prevention drug strategies.
Antonino Tuttolomondo,Rosaria Pecoraro,Domenico Di Raimondo,Valentina Arnao,Giuseppe Clemente,Vittoriano Della Corte,Carlo Maida,Irene Simonetta,Giuseppe Licata,Antonio Pinto +9 more
TL;DR: Experimental and clinical data suggest that reducing the activity of the renin-angiotensin aldosterone system (RAAS) may have beneficial effects beyond the lowering of blood pressure to reduce stroke incidence.
Journal Article
Predictors of warfarin use in patients with non-valvular atrial fibrillation who presented to the cardiology outpatient clinic of a tertiary hospital in Turkey: an observational study
Faruk Ertaş,Hasan Kaya,Zuhal Arıtürk Atılgan,Mehmet Ali Elbey,Mesut Aydin,Mehmet Ata Akıl,Mustafa Oylumlu,Mehmet Sıddık Ülgen +7 more
TL;DR: It is demonstrated that a history of stroke or SE, high income level, presence of persistent and permanent AF, and advanced age are independent predictors of warfarin use in non-valvular AF patients.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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