Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Effectiveness of fixed minidose warfarin in the prevention of thromboembolism and vascular death in nonrheumatic atrial fibrillation
Vittorio Pengo,A Zasso,Fabio Barbero,Alberto Banzato,Giovanni Nante,Lucia Parissenti,Nancy John,Franco Noventa,Sergio Dalla Volta +8 more
TL;DR: In this article, fixed minidose warfarin (1.25 mg/day) or standard adjusted-dose warin (International Normalized Ratio [INR] between 2.0 and 3.0) was used to prevent venous thromboembolism with low risk of bleeding and no need for frequent clinical monitoring.
Journal ArticleDOI
Prevention of thromboembolism in atrial fibrillation. A meta-analysis of trials of anticoagulants and antiplatelet drugs.
Jodi B Segal,Robert L. McNamara,Robert L. McNamara,Marlene R. Miller,Nina Kim,Nina Kim,Steven N. Goodman,Neil R. Powe,Neil R. Powe,Karen A. Robinson,Karen A. Robinson,Eric B. Bass +11 more
TL;DR: The evidence strongly supports warfarin for patients with AF at average or greater risk of stroke, and aspirin may prove to be useful in subgroups with a low risk of Stroke, although this is not definitively supported by the evidence.
Journal ArticleDOI
Initial experience with the maze procedure for atrial fibrillation.
Patrick M. McCarthy,Lon W. Castle,James D. Maloney,Richard G. Trohman,Tony W. Simmons,Richard D. White,Allan L. Klein,Delos M. Cosgrove +7 more
TL;DR: The maze procedure is an extensive operation but is indicated for selected patients who have the severe sequelae of atrial fibrillation who are receiving no antiarrhythmic medications, have sinus rhythm, or have p-wave tracking with ventricular pacing.
Journal ArticleDOI
Low incidence of stroke in ambulatory patients with heart failure: A prospective study
Stuart D. Katz,Paul R. Marantz,Luigi M. Biasucci,Guillaume Jondeau,Kevin Lee,Claudia Brennan,Thierry H. LeJemtel +6 more
TL;DR: Two-dimensional echocardiographic studies, performed for clinical indications other than previous systemic thromboembolism in 109 patients, were analyzed to relate the presence of left ventricular thrombus to subsequent outcome, and known risk factors for stroke were present in all nine patients with cerebral thrombaembolic events.
Journal ArticleDOI
Anticoagulants for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischaemic attack.
TL;DR: The evidence suggests that anticoagulants are beneficial, without serious adverse effects, for people with nonrheumatic atrial fibrillation and recent cerebral ischaemia.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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