Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Net Efficacy Adjusted for Risk (NEAR): A Simple Procedure for Measuring Risk:Benefit Balance
TL;DR: The objective was to design a simple, easily applicable model that represents “net efficacy adjusted for risk” (NEAR) representing overall risk-benefit, and to contribute to improving knowledge of drug clinical usefulness.
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UtilizaciÓn de anticoagulantes orales en pacientes con fibrilaciÓn auricular al alta hospitalaria en el año 2000
Pedro Blanch,Roman Freixa,Montserrat Ibernón,Javier Delso,Elena Salas,José Luis Sobrepera,Jaume Padró,Laura Dos,Pedro Codinach +8 more
TL;DR: El tratamiento anticoagulante oral se administro en una insuficiente proporcion de pacientes con fibrilacion auricular, sin contraindicaciones para recibir dicha terapia, que fueron dados de alta de un hospital de segundo nivel.
Journal ArticleDOI
Stroke prevention in atrial fibrillation: WATCHMAN versus warfarin
David R. Holmes,Rebecca Fountain +1 more
TL;DR: The cornerstone of stroke prevention in patients with atrial fibrillation is warfarin, which has been tested in multiple trials against placebo, aspirin alone (ASA), or aspirin in combination with clopidogrel and was found to be more effective than aspirin alone in preventing stroke.
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Atrial fibrillation in patients with end-stage renal disease on hemodialysis: Magnitude of the problem and new approach to oral anticoagulation.
Oliver Königsbrügge,Cihan Ay +1 more
TL;DR: There is no evidence to support efficacy and safety of direct oral anticoagulants compared to vitamin K antagonists in HD patients, and the pharmacological characteristics of DOACs are of particular interest in the HD setting.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
Mg Ceravolo,Leandro Provinciali +1 more