Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Prevalence of Bleeding Complications Following Ultrasound-Guided Botulinum Toxin Injections in Patients on Anticoagulation or Antiplatelet Therapy
TL;DR: Patients receiving anticoagulation or antiplatelet therapy may be at higher risk for bleeding complications following intramuscular chemodenervation injections and Musculoskeletal ultrasound may be able to reduce the risk of bleeding complications by providing real‐time visualization of vascular structures and postinjection monitoring.
Journal ArticleDOI
Empleo de fármacos antitrombóticos en pacientes hipertensos con fibrilación auricular crónica. Estudio CARDIOTENS 99
Vicente Bertomeu Martínez,Pedro J Morillas Blasco,José Ramón González Juanatey,Eduardo Alegría Ezquerra,José María García Acuña,Isidoro González Maqueda,Araceli Frutos García,Ricardo Valero Parra,José Angel Rodríguez Ortega +8 more
TL;DR: In this paper, the authors investigate the degree real de anticoagulación and antiagregation of fibrilacion auricular cronica in the pacientes hipertensos in the practica diariaen Espana and analizar si existen diferencias entre el medico de atencion primaria and the especialista en cardiologia.
Journal ArticleDOI
Long-Term Risk of Stroke in Myocardial Infarction Survivors: Thirty-Year Population-Based Cohort Study.
Jens Sundbøll,Erzsébet Horváth-Puhó,Morten Schmidt,Lars Pedersen,Victor W. Henderson,Hans Erik Bøtker,Henrik Toft Sørensen +6 more
TL;DR: MI was a risk factor for all stroke subtypes during the first year of follow-up, but only for ischemic stroke thereafter.
Journal ArticleDOI
Warfarin in the secondary prevention of thromboembolism in atrial fibrillation: impact of bioavailability on costs and outcomes.
Nicole Mittmann,Nicole Mittmann,Paul Oh,Paul Oh,Scott E. Walker,Scott E. Walker,William R. Bartle,William R. Bartle +7 more
TL;DR: In patients with atrial fibrillation and a prior ischaemic stroke or transient ischaemia attack, the use of one warfarin agent within the range of acceptable bioavailability can be considered economically attractive from the healthcare perspective.
Journal ArticleDOI
ANTIPLATELET THERAPY: Aspirin, Ticlopidine/Clopidogrel, and Anti-Integrin Agents
TL;DR: Pharmacologic considerations and current clinical knowledge relevant to the use of aspirin, ticlopidine, clopidogrel, and the GPIIbIIIa antagonists in the management of thrombotic disorders are outlined.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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