SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19.
Alba Grifoni,John Sidney,Randi Vita,Bjoern Peters,Shane Crotty,Shane Crotty,Daniela Weiskopf,Alessandro Sette,Alessandro Sette +8 more
TLDR
In this article, the authors reviewed how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance.About:
This article is published in Cell Host & Microbe.The article was published on 2021-07-14 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Epitope.read more
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The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao,Philip L Tzou,Janin Nouhin,Ravindra K. Gupta,Tulio de Oliveira,Sergei L Kosakovsky Pond,Daniela Fera,Robert W. Shafer +7 more
TL;DR: The emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic has been witnessed as mentioned in this paper.
Journal ArticleDOI
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
Alison Tarke,Camila H. Coelho,Zeli Zhang,Jennifer M. Dan,Esther Dawen Yu,Nils Methot,Nathan Bloom,Benjamin Goodwin,Elizabeth J. Phillips,Simon Mallal,John Sidney,Gilberto Filaci,Daniela Weiskopf,Ricardo da Silva Antunes,Shane Crotty,Alba Grifoni,Alessandro Sette +16 more
TL;DR: In this paper , the authors address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS CoV-2 variants.
Journal ArticleDOI
T cell responses to SARS-CoV-2 spike cross-recognize Omicron
Roanne Keeton,Marius Belmondo Tincho,Amkele Ngomti,Richard Baguma,N. Benede,Akiko Suzuki,Khadija Khan,Sandile Cele,Mallory Bernstein,Farina Karim,Sharon Madzorera,Thandeka Moyo-Gwete,M. Mennen,S. Skelem,M. Adriaanse,Daniel Mutithu,Olukayode O. Aremu,Cari Stek,Elsa Du Bruyn,M. A. Van Der Mescht,Zelda de Beer,T. R. de Villiers,Anne Brunhilde Bodenstein,Gretha van den Berg,Adriano Mendes,Amy Strydom,Marietjie Venter,Jennifer Giandhari,Yeshnee Naidoo,Sureshnee Pillay,Houriiyah Tegally,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Robert J. Wilkinson,Tulio de Oliveira,Linda-Gail Bekker,Glenda Gray,Veronica Ueckermann,Theresa M. Rossouw,Michael T. Boswell,Jinal N. Bhiman,Penny L. Moore,Alex Sigal,Ntobeko A.B. Ntusi,Wendy A. Burgers,Catherine Riou +46 more
TL;DR: In this paper , the authors assessed the ability of T cells to react to Omicron spike protein in participants who were vaccinated with Ad26.S or BNT162b2, or unvaccinated convalescent COVID-19 patients.
Journal ArticleDOI
Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients
Corine H. GeurtsvanKessel,D. Geers,Katharina S. Schmitz,Anna Z Mykytyn,Mart M. Lamers,Susanne Bogers,Sandra M.J. Scherbeijn,L. Gommers,Roos S G Sablerolles,N. Nieuwkoop,Laurine C Rijsbergen,Laura J. A. van Dijk,J. de Wilde,Kimberley Alblas,Tim I Breugem,Bart J. A. Rijnders,Herbert de Jager,Daniela Weiskopf,P. H. M. van der Kuy,Alessandro Sette,Marion Koopmans,Alba Grifoni,Bart L. Haagmans,Rory D. de Vries +23 more
TL;DR: This study shows that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, potentially balancing the lack of neutralizing antibodies in preventing or limiting severe COVID-19 cases.
Journal ArticleDOI
Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells.
Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Zeli Zhang,Carolyn Rydyznski Moderbacher,Marshall Lammers,Benjamin Goodwin,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty,Daniela Weiskopf +11 more
TL;DR: Vaccine-specific CD4+ T cell, CD8+T cell, binding antibody, and neutralizing antibody responses to the 25-μg Moderna messenger RNA (mRNA)-1273 vaccine were examined over the course of 7 months as mentioned in this paper.
References
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Book
Cellular and Molecular Immunology
TL;DR: Cellular and molecular immunology , Cellular and molecular Immunology , کتابخانه الکرونیک و دیجیتال - آذرسا
Journal ArticleDOI
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
Book
Janeway's immunobiology
TL;DR: The Evolution of the Immune System Appendix I Immunologists' Toolbox Appendix II CD Antigens Appendix III Cytokines and their Receptors Appendix IV Chemokinesand their Receptionors Appendix V Immunological Constants.
Journal ArticleDOI
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7.
Pengfei Wang,Manoj S. Nair,Lihong Liu,Sho Iketani,Sho Iketani,Yang Luo,Yicheng Guo,Maple Wang,Jian Yu,Baoshan Zhang,Peter D. Kwong,Peter D. Kwong,Barney S. Graham,John R. Mascola,Jennifer Y Chang,Jennifer Y Chang,Michael T. Yin,Michael T. Yin,Magdalena E. Sobieszczyk,Magdalena E. Sobieszczyk,Christos A. Kyratsous,Lawrence Shapiro,Lawrence Shapiro,Zizhang Sheng,Yaoxing Huang,David D. Ho,David D. Ho +26 more
TL;DR: In this paper, the authors show that B.1.7 is refractory to neutralization by most monoclonal antibodies against the N-terminal domain of the spike protein and is relatively resistant to a few monoclanal antibody against the receptor-binding domain.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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