The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
TLDR
Adiponectin was effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice and could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine.Abstract:
Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss without affecting food intake. Here we report its potential roles in alcoholic and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food. Delivery of recombinant adiponectin into these mice dramatically alleviated hepatomegaly and steatosis (fatty liver) and also significantly attenuated inflammation and the elevated levels of serum alanine aminotransferase. These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin treatment could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases.read more
Citations
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LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells
LaTonia Taliaferro-Smith,Arumugam Nagalingam,D Zhong,Wei Zhou,Neeraj K. Saxena,Dipali Sharma +5 more
TL;DR: A novel mechanism involving specific upregulation of tumor suppressor gene LKB1 is presented by which adiponectin inhibits adhesion, invasion and migration of breast cancer cells.
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Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease.
Kerry-Lee Milner,David van der Poorten,Aimin Xu,Elisabetta Bugianesi,James G. Kench,Karen S.L. Lam,Donald J. Chisholm,Jacob George +7 more
TL;DR: Circulating AFABP, produced by adipocytes and macrophages, and lipocalin‐2,produced by multiple tissues, are elevated and may contribute to the metabolic syndrome in NAFLD and have a direct pathogenic link to disease progression.
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Adipocytokines and liver disease
TL;DR: The association of adipocytokines, especially leptin, adiponectin, TNF-α, and resistin, with liver diseases is discussed.
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Pathophysiology of NASH: perspectives for a targeted treatment.
Fabio Marra,Sophie Lotersztajn +1 more
TL;DR: The major mechanisms leading to appearance and progression of NASH are reviewed, focusing on both extrahepatic signals and local inflammatory mechanisms, in an effort to identify the most promising molecular targets for the treatment of this condition.
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Adiponectin: a versatile player of innate immunity
Yan Luo,Meilian Liu +1 more
TL;DR: It is shown that adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions and the mechanisms underlying the role of adip onectin in regulating innate immunity are defined.
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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
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Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
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TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
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