The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
TLDR
Adiponectin was effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice and could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine.Abstract:
Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss without affecting food intake. Here we report its potential roles in alcoholic and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food. Delivery of recombinant adiponectin into these mice dramatically alleviated hepatomegaly and steatosis (fatty liver) and also significantly attenuated inflammation and the elevated levels of serum alanine aminotransferase. These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin treatment could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases.read more
Citations
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Journal ArticleDOI
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice†
Masato Tsuchiya,Masato Tsuchiya,Cheng Ji,Oksana Kosyk,Svitlana Shymonyak,Stepan Melnyk,Hiroshi Kono,Volodymyr Tryndyak,Levan Muskhelishvili,Igor P. Pogribny,Neil Kaplowitz,Ivan Rusyn +11 more
TL;DR: It is demonstrated that strain differences in alcohol‐induced liver injury and steatosis are striking and independent of alcohol exposure and the most severely affected strains exhibit major differences in the expression of ER stress markers and genes of one‐carbon metabolism.
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Peroxisome proliferator-activated receptors: Bridging metabolic syndrome with molecular nutrition
TL;DR: By learning about the mechanisms and tissue-specific effects of endogenous PPAR ligands and expanding the knowledge of the body's integrated homeostatic system, the odds of designing safe and effective preventive and therapeutic interventions that keep us one step ahead of obesity-related diseases will significantly increase.
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Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism
TL;DR: These findings show that daidzein might alleviate NAFLD through the direct regulation of hepatic de novo lipogenesis and insulin signaling, and the indirect control of adiposity and adipocytokines by the alteration of adipocyte metabolism.
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Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease
Cosmin Sebastian Voican,Micheline Njiké-Nakseu,Hédia Boujedidi,N. Barri-Ova,Laurence Bouchet-Delbos,Hélène Agostini,Sophie Maitre,Sophie Prevot,Anne-Marie Cassard-Doulcier,Sylvie Naveau,Gabriel Perlemuter +10 more
TL;DR: Patients with alcoholic liver disease display inflammation of the subcutaneous adipose tissue (SAT) which correlates with liver lesions and the consequences of alcohol withdrawal are studied.
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Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet
Hiroshi Araki,Tamao Nishihara,Morihiro Matsuda,Atsunori Fukuhara,Shinji Kihara,Tohru Funahashi,Tatsuki R Kataoka,Yoshihiro Kamada,Tatsuya Kiyohara,Shinji Tamura,Norio Hayashi,Iichiro Shimomura +11 more
TL;DR: The role of adiponectin in acute pancreatitis (AP) has not been investigated as discussed by the authors, but the molecular mechanism remains unclear, however, the role of AP has been found to play a protective role in caerulein-induced AP in obese mice.
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TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
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