The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
TLDR
Adiponectin was effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice and could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine.Abstract:
Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss without affecting food intake. Here we report its potential roles in alcoholic and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food. Delivery of recombinant adiponectin into these mice dramatically alleviated hepatomegaly and steatosis (fatty liver) and also significantly attenuated inflammation and the elevated levels of serum alanine aminotransferase. These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin treatment could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases.read more
Citations
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Characterization of Adipose Tissue Inflammation in Alcoholic Liver Disease
TL;DR: It is demonstrated that female mice have greater alcohol-induced adipose tissue inflammation than male mice, evidenced by greater expression of pro-inflammatory cytokines and cell markers and a potential role for the innate immune system in alcohol- induced adipose inflammation.
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The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease.
TL;DR: Wang et al. as mentioned in this paper investigated the effects of Pien Tze Huang (PTH), a well-known traditional Chinese herbal formula with liver protective effect, in methionine-choline deficient diet (MCD)- and high-fat diet (HFD)-induced NASH mouse models.
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Liver damage in an experimental model of peripheral neuropathy induced by Karwinskia humboldtiana (Buckthorn) fruit: Histopathological evidence
Rubén García-Garza,Martha E. Salazar-Leal,Viktor J. Romero-DÃaz,Jaime García-Juárez,Carlos Leyva-Orasma,Javier Morán-Martínez,Odila Saucedo-Cárdenas,Adolfo Soto-DomÃnguez +7 more
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La stéatohépatite non alcoolique
V. Ratziu,M. Tahiri,L. Bonyhay +2 more
TL;DR: La steatohepatite non alcoolique (NASH) est une condition pathologique caracterisee par un depot excessif de lipides dans le foie (steatose), une inflammation and une necrose hepato-cellulaire, which peut avoir un pronostic pejoratif chez une minorite de patients.
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Green tea extract increases adiponectin and PPARα levels to improve hepatic steatosis.
Marcelo Paradiso Marinovic,Celso Pereira Batista Sousa-Filho,Freire Batista,Thayna Mendonca Avelino,Beatrice Cogliati,Ana Carolina Migliorini Figueira,Rosemari Otton,Augusto Cezar Rodrigues +7 more
TL;DR: This article showed that green tea (GT) improves in non-alcoholic fatty liver disease (NAFLD) are dependent on adiponectin action in the liver and showed that GT catechins act to improve hepatic steatosis by measuring lipid accumulation, and transcript levels of lipogenic genes in HepG2 cells treated with GT in the presence of a PPAR antagonist.
References
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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
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TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Journal ArticleDOI
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Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
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TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
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