The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity
TL;DR: Pyr is the first demonstrated transmembrane FGF, that it has both extracellular and intracellular functions, and that spatial distribution and levels of this particular FGF protein are tightly regulated, and the results suggest that other FGFs may be membrane tethered or multifunctional like Pyr.
Journal ArticleDOI
FGF signaling acts on different levels of mesoderm development within Spiralia
Carmen Andrikou,Andreas Hejnol +1 more
TL;DR: In this article, the role of FGF signaling in mesoderm development in three species of lophophorates, a clade within the protostome group Spiralia, was investigated.
Journal ArticleDOI
The "Angiogenic Switch" and Functional Resources in Cyclic Sports Athletes.
Olga V Balberova,E.V. Bykov,Natalia Shnayder,Marina M. Petrova,Oksana A. Gavrilyuk,Daria S Kaskaeva,Irina A Soloveva,Kirill V Petrov,Elena Mozheyko,German V Medvedev,R. F. Nasyrova +10 more
TL;DR: A review of publications on signaling pathways that activate and inhibit angiogenesis in skeletal muscles, myocardium, lung, and nervous tissue under the influence of intense physical activity in cyclic sports is presented in this article.
Dissertation
Autophagy in Head and Neck Cancer Associated Fibroblasts
TL;DR: It is suggested that within the context of a youth-services agency using a mobile application, the use of a tablet computer is more beneficial than using a traditional one-size-fits-all approach.
Journal ArticleDOI
Members of the Fibroblast Growth Factor Receptor Superfamily Are Proteolytically Cleaved by Two Differently Activated Metalloproteases.
TL;DR: In this article, the authors demonstrate that metalloprotease-dependent metallopease family, ADAM10 and ADAM17, are differentially regulated FGFR membrane sheddases and may therefore provide new insight into the regulation of FGFR functions.
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TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
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