The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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The use of heparin and heparin-like molecules in cancer treatment: a review
TL;DR: Although limited clinical evidence of efficacy and potential pitfalls are present, heparin and hepar in-like molecules have shown potential in the management of cancer patients.
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FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1
TL;DR: Due to the diversified mode of action the dual warhead-FGF2 conjugate may overcome the potential acquired resistance of FGFR1-overproducing cancer cells towards single cytotoxic drugs.
Journal ArticleDOI
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.
Ankur Garg,Mukesh Bansal,Noriko Gotoh,Gen-Sheng Feng,Jian Zhong,Fen Wang,Ariana Kariminejad,Steven E. Brooks,Xin Zhang +8 more
TL;DR: It is shown that Shp2 exclusively mediates FGF but not PDGF signaling in the neural crest to control lacrimal gland development, and that Alx4 binds an Fgf10 intronic element conserved in terrestrial but not aquatic animals, underlying the evolutionary emergence of the lacrima gland system in response to an airy environment.
Journal ArticleDOI
The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling.
Manon Destalminil-Letourneau,Ismaël Morin-Poulard,Yushun Tian,Nathalie Vanzo,Michèle Crozatier +4 more
TL;DR: In this article, the vascular system acts as a second niche to control lymph gland homeostasis, and the FGF ligand Branchless produced by vascular cells activates the pathway in hematopoietic progenitors.
Journal ArticleDOI
Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure).
Susan Stienen,João Pedro Ferreira,João Pedro Ferreira,Masatake Kobayashi,Gregoire Preud'homme,Daniela Dobre,Jean-Loup Machu,Kevin Duarte,Emmanuel Bresso,Marie-Dominique Devignes,Natalia López,Nicolas Girerd,Svend Aakhus,Svend Aakhus,Giuseppe Ambrosio,Hans-Peter Brunner-La Rocca,Ricardo Fontes-Carvalho,Alan G. Fraser,Loek van Heerebeek,Stephane Heymans,Stephane Heymans,Stephane Heymans,Gilles W. De Keulenaer,Paolo Marino,Kenneth McDonald,Alexandre Mebazaa,Zoltán Papp,Riccardo Raddino,Carsten Tschöpe,Walter Paulus,Faiez Zannad,Patrick Rossignol +31 more
TL;DR: It was demonstrated that biomarkers associated with the high- risk cluster were related to the immune system, signal transduction cascades, cell interactions and metabolism, which may help select high-risk HFpEF patients most likely to respond to the selected mechanistically targeted therapies.
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