The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Tumor angiogenesis: causes, consequences, challenges and opportunities.
TL;DR: The current understanding of cellular and molecular mechanisms involved in tumor angiogenesis is summarized and challenges and opportunities associated with vascular targeting are discussed.
Journal ArticleDOI
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.
Arun J. Sanyal,Edgar D. Charles,Brent A. Neuschwander-Tetri,Rohit Loomba,Stephen A. Harrison,Manal F. Abdelmalek,Eric Lawitz,Dina Halegoua-DeMarzio,Sudeep Kundu,Stephanie Noviello,Yi Luo,Rose C. Christian +11 more
TL;DR: Treatment with subcutaneously administered pegbelfermin for 16 weeks was generally well tolerated and significantly reduced hepatic fat fraction in patients with non-alcoholic steatohepatitis, and the full planned sample size was not needed.
Journal ArticleDOI
Fibroblast growth factor signaling in skeletal development and disease
TL;DR: Progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis is examined, and the mechanisms by which mutations in FGF signalling molecules cause skeletal malformations in humans are explored.
Journal ArticleDOI
The molecular basis of endothelial cell plasticity
TL;DR: The endothelium is capable of remarkable plasticity in the embryo and in the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input that leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases.
Journal ArticleDOI
Classifying the evolutionary and ecological features of neoplasms
Carlo C. Maley,Athena Aktipis,Trevor A. Graham,Andrea Sottoriva,Amy M. Boddy,Michalina Janiszewska,Ariosto S. Silva,Marco Gerlinger,Yinyin Yuan,Kenneth J. Pienta,Karen S. Anderson,Robert A. Gatenby,Charles Swanton,David Posada,Chung I. Wu,Joshua D. Schiffman,E. Shelley Hwang,Kornelia Polyak,Alexander R. A. Anderson,Joel S. Brown,Mel Greaves,Darryl Shibata +21 more
TL;DR: A framework for classifying tumours is proposed that holds promise for enabling clinicians to personalize optimal interventions based on the evolvability of the patient's tumour, and the Evo- and Eco-indices provide a common lexicon for communicating about how neoplasms change in response to interventions.
References
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Journal ArticleDOI
Essential roles of zebrafish bmp2a, fgf10 and fgf24 in the specification of the ventral pancreas
François Naye,Marianne Voz,Nathalie Detry,Matthias Hammerschmidt,Bernard Peers,Isabelle Manfroid +5 more
TL;DR: In vertebrates, pancreas and liver arise from bipotential progenitors located in the endoderm, and at early stages, BMP and FGF are known to promote liver fate at the expense of Pancreas, whereas they have an opposite effect on liver development.
Journal ArticleDOI
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
Monika Jarosz,Luisa Robbez-Masson,Athina-Myrto Chioni,Barbara Cross,Ian Rosewell,Richard Grose +5 more
TL;DR: Despite the known expression profile of FGF22 in the skin, no differences in either skin or pelage were observed, demonstrating that FGF 22 is dispensable during embryogenesis and in unchallenged adult skin.
Journal ArticleDOI
Fgfr3 regulates development of the caudal telencephalon
Randal X. Moldrich,Cecilia Mezzera,William M. Holmes,Sailaja Goda,Sam J. Brookfield,Alastair J Rankin,Emily Barr,Nyoman D. Kurniawan,Deborah Dewar,Linda J. Richards,Guillermina López-Bendito,Tomoko Iwata +11 more
TL;DR: The results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections, as well as a subtle thalamocortical tract deficit, detected by dye‐tracing and diffusion magnetic resonance imaging and tractography.
Journal ArticleDOI
A functional polymorphism at the FGF10 gene is associated with extreme myopia.
Edward Hsi,Ku-Chung Chen,Ku-Chung Chen,Wan-Shu Chang,Ming-Lung Yu,Chung-Ling Liang,Suh-Hang Hank Juo +6 more
TL;DR: It is concluded that the FGF10 could have been involved in the development of myopia and the risk G allele of SNP rs339501 was associated with extreme myopia in human and caused a higher gene expression in the luciferase assay.
Journal ArticleDOI
The FgfrL1 receptor is required for development of slow muscle fibers
TL;DR: It is shown that the diaphragm of FgfrL1 knockout animals lacks any slow muscle fibers at E18.5 as indicated by the absence of slow fiber markers Myh7, Myl2 and Myl3.
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