The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Making sense of giant cell lesions of the jaws (GCLJ): lessons learned from next-generation sequencing
Carolina Cavalieri Gomes,Marina Gonçalves Diniz,Victor Coutinho Bastos,Vanessa Fátima Bernardes,Ricardo Santiago Gomez +4 more
TL;DR: Based on recent results, the pathogenesis of a subgroup of sporadic GCLJ seems closely related to non‐ossifying fibroma of long bones, with both lesions sharing MAPK pathway‐activating mutations.
Journal ArticleDOI
VEGF and FGF signaling during head regeneration in hydra.
TL;DR: The results suggest that VEGF and FGF signaling play important roles in regeneration of hypostome and tentacles in hydra.
Journal ArticleDOI
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.
Norihiko Sasaki,Fujiya Gomi,Hisashi Yoshimura,Masami Yamamoto,Yoko Matsuda,Masaki Michishita,Hitoshi Hatakeyama,Yoichi Kawano,Masashi Toyoda,Murray Korc,Toshiyuki Ishiwata +10 more
TL;DR: It is proposed that BLU9931 is a promising therapeutic agent in FGFR4-positive PDAC, especially when combined with senolysis, and could provide a novel therapeutic strategy in patients whose PDAC expresses highFGFR4 levels.
Journal ArticleDOI
Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development.
Lanlan Chen,Lanlan Chen,Xiaoheng Li,Yiyan Wang,Tiantian Song,Huitao Li,Lubin Xie,Linchao Li,Xianwu Chen,Leikai Ma,Yong Chen,Yao Lv,Xingwang Li,Ren-Shan Ge +13 more
TL;DR: The effects of FGF1 on rat stem Leydig cell development in an ethane dimethane sulfonate (EDS)-treated model shows that FGF 1 promotes stem Leydenig cell proliferation but blocks its differentiation.
Journal ArticleDOI
Non-Cell-Autonomous Mechanisms in Radial Projection Neuron Migration in the Developing Cerebral Cortex.
Andi H. Hansen,Simon Hippenmeyer +1 more
TL;DR: Different models of non-cell-autonomous interactions of cortical projection neurons along their radial migration trajectory during development are outlined and key questions to address are defined.
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