The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes.
Yu-Qing Lv,Yu-Qing Lv,Qhaweni Dhlamini,Chengshui Chen,Xiaokun Li,Saverio Bellusci,Saverio Bellusci,Jin-San Zhang,Jin-San Zhang +8 more
TL;DR: In this paper, a review summarizes the current understanding of the role of FGF10 in adipocytes, while attempting to derive insights on the existing literature and extrapolate the knowledge to pulmonary lipofibroblasts.
Journal ArticleDOI
Integration of tooth morphogenesis and innervation by local tissue interactions, signaling networks, and semaphorin 3A
Keijo Luukko,Päivi Kettunen +1 more
TL;DR: SEMA3A driven axon guidance is integrated into key odontogenic signaling networks, establishing this protein as a critical molecular tether between 2 distinct developmental processes (morphogenesis and sensory innervation), both of which are required to obtain a functional tooth.
Journal ArticleDOI
Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis.
Joanna Góralska,Urszula Raźny,Anna Polus,Agnieszka Dziewońska,Anna Gruca,Anna Zdzienicka,Aldona Dembinska-Kiec,Bogdan Solnica,Agnieszka Micek,Maria Kapusta,Krystyna Slowinska-Solnica,Małgorzata Malczewska-Malec +11 more
TL;DR: Exaggerated fasting and postprandial secretion of GIP in obesity are associated with elevated liver damage markers as well as FGF-21 plasma levels, and differential expressed microRNAs suggest additional, epigenetic factors contributing to the gut–liver cross-talk.
Journal ArticleDOI
Organization at criticality enables processing of time-varying signals by receptor networks.
TL;DR: Using the experimentally established epidermal growth factor sensing system, it is proposed how recycling could provide self‐organized maintenance of the critical receptor concentration at the plasma membrane through a simple, fluctuation‐sensing mechanism.
Journal ArticleDOI
Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology.
Lucía Saucedo,Cristian Marcelo Sobarzo,Nicolás Gastón Brukman,Héctor Alejandro Guidobaldi,Livia Lustig,Laura Cecilia Giojalas,Mariano G. Buffone,Mónica H. Vazquez-Levin,Clara I. Marín-Briggiler +8 more
TL;DR: This study shows that FGF2 is expressed in tissues of the female reproductive tract, and the fact that functional FGFRs are present in mouse sperm and that rFGF2 affects sperm motility and acrosomal exocytosis, suggests the involvement of this system in the in vivo regulation of sperm function.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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