The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Tumor angiogenesis: causes, consequences, challenges and opportunities.
TL;DR: The current understanding of cellular and molecular mechanisms involved in tumor angiogenesis is summarized and challenges and opportunities associated with vascular targeting are discussed.
Journal ArticleDOI
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.
Arun J. Sanyal,Edgar D. Charles,Brent A. Neuschwander-Tetri,Rohit Loomba,Stephen A. Harrison,Manal F. Abdelmalek,Eric Lawitz,Dina Halegoua-DeMarzio,Sudeep Kundu,Stephanie Noviello,Yi Luo,Rose C. Christian +11 more
TL;DR: Treatment with subcutaneously administered pegbelfermin for 16 weeks was generally well tolerated and significantly reduced hepatic fat fraction in patients with non-alcoholic steatohepatitis, and the full planned sample size was not needed.
Journal ArticleDOI
Fibroblast growth factor signaling in skeletal development and disease
TL;DR: Progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis is examined, and the mechanisms by which mutations in FGF signalling molecules cause skeletal malformations in humans are explored.
Journal ArticleDOI
The molecular basis of endothelial cell plasticity
TL;DR: The endothelium is capable of remarkable plasticity in the embryo and in the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input that leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases.
Journal ArticleDOI
Classifying the evolutionary and ecological features of neoplasms
Carlo C. Maley,Athena Aktipis,Trevor A. Graham,Andrea Sottoriva,Amy M. Boddy,Michalina Janiszewska,Ariosto S. Silva,Marco Gerlinger,Yinyin Yuan,Kenneth J. Pienta,Karen S. Anderson,Robert A. Gatenby,Charles Swanton,David Posada,Chung I. Wu,Joshua D. Schiffman,E. Shelley Hwang,Kornelia Polyak,Alexander R. A. Anderson,Joel S. Brown,Mel Greaves,Darryl Shibata +21 more
TL;DR: A framework for classifying tumours is proposed that holds promise for enabling clinicians to personalize optimal interventions based on the evolvability of the patient's tumour, and the Evo- and Eco-indices provide a common lexicon for communicating about how neoplasms change in response to interventions.
References
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Journal ArticleDOI
Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genes.
Neville Mistry,Whitney Harrington,Erika Lasda,Eric J. Wagner,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +5 more
TL;DR: A phylogenetic analysis from a sea urchin to humans of the alternativesplicing unit encoding the third Ig domain of fibroblast growth factor receptors indicates that the mechanisms that regulate this alternative splicing unit evolved over 600 million years ago.
Journal ArticleDOI
LAMM syndrome with middle ear dysplasia associated with compound heterozygosity for FGF3 mutations.
Alberto Sensi,S. Ceruti,Patrizia Trevisi,Francesca Gualandi,Micol Busi,Ilaria Donati,Marcella Neri,Alessandra Ferlini,Alessandro Martini +8 more
TL;DR: It is confirmed the absence of otodental syndrome in heterozygous carriers, but report unilateral microtia in one of them, and the involvement of the middle ear structures in LAMM Syndrome is reported.
Journal ArticleDOI
The fibroblast growth factor receptor-4 Arg388 allele is associated with gastric cancer progression
Yanwei Ye,Yingqiang Shi,Ye Zhou,Chunyan Du,Chunmeng Wang,Heqin Zhan,Biqiang Zheng,Xi Cao,Meng Hong Sun,Hong Fu +9 more
TL;DR: Based on this study, FGFR4 Arg388 genotype—a marker for gastric cancer progression—may predict prognosis of Gastric cancer.
Journal ArticleDOI
Autocrine/paracrine action of vitamin D on FGF23 expression in cultured rat osteoblasts.
TL;DR: The results suggested that upregulation of FGF23 in differentiated osteoblasts appeared to be due to increased autocrine/paracrine action of osteoblast-derived 1α,25(OH)2D and increased cell communication, which were identified in cultured rat calvaria osteoblast.
Journal ArticleDOI
Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk.
Hae Jong Kim,Kyeoung-Hwa Kim,Jaehyouk Lee,Jong Jin Oh,Hyun Sub Cheong,Ee Lin Wong,Beom-Seok Yang,Seok-Soo Byun,Soon Chul Myung +8 more
TL;DR: To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population, a genome-wide association study is conducted.
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