The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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FGF9 mutation causes craniosynostosis along with multiple synostoses.
Maria Rodriguez-Zabala,Miriam Aza-Carmona,Miriam Aza-Carmona,Miriam Aza-Carmona,Carlos I. Rivera-Pedroza,Carlos I. Rivera-Pedroza,Alberta Belinchón,Alberta Belinchón,Alberta Belinchón,Isabel Guerrero‐Zapata,Jimena Barraza-García,Jimena Barraza-García,Jimena Barraza-García,Elena Vallespín,Elena Vallespín,Min Lu,Angela del Pozo,Angela del Pozo,Marc J. Glucksman,Fernando Santos-Simarro,Fernando Santos-Simarro,Fernando Santos-Simarro,Karen E. Heath,Karen E. Heath,Karen E. Heath +24 more
TL;DR: It is demonstrated for the first time that mutations in FGF9 cause craniosynostosis in humans and confirmed that FGF 9 mutations cause multiple synostoses.
Journal ArticleDOI
Suppression of TGF-β and ERK Signaling Pathways as a New Strategy to Provide Rodent and Non-Rodent Pluripotent Stem Cells.
Maryam Farzaneh,Zahra Derakhshan,Jamal Hallajzadeh,Neda Hosseini Sarani,Armin Nejabatdoust,Seyed Esmaeil Khoshnam +5 more
TL;DR: Recently emerging evidence that dual inhibition of TGF-β and FGF signaling pathways plays an important role in regulating pluripotency in both rodent and non-rodent pluripotent stem cells is discussed.
Journal ArticleDOI
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium.
Abha Sahni,Jignesh Patel,Hema P. Narra,Casey L. C. Schroeder,David H. Walker,Sanjeev K. Sahni +5 more
TL;DR: Host cell FGFR1 and rickettsial OmpA are identified as another novel receptor-ligand pair contributing to the internalization of pathogenic ricksettsiae into host endothelial cells and the potential application of FGFR-inhibitor drugs as adjunct therapeutics against spotted fever ricktsioses is identified.
Journal ArticleDOI
FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis.
TL;DR: In this paper, the role of the FGF signalling pathway during skeletal development in embryos and arm regeneration in the brittle star Amphiura filiformis has been investigated in a comparative analysis.
Journal ArticleDOI
Phosphoproteomics of Fibroblast Growth Factor 1 (FGF1) Signaling in Chondrocytes: Identifying the Signature of Inhibitory Response.
Jessica R. Chapman,Olga Katsara,Rachel Ruoff,David Morgenstern,Shruti Nayak,Claudio Basilico,Beatrix Ueberheide,Victoria Kolupaeva +7 more
TL;DR: G glycogen synthase kinase3β (GSK3β) is discovered as a novel key mediator of FGF inhibitory response in chondrocytes, the first time a comprehensive subset of proteins involved in FGF inhibitsory response is defined.
References
More filters
Journal ArticleDOI
AKT/PKB signaling: navigating downstream.
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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