The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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miR-129 Blocks Secondary Hyperparathyroidism-Inducing Fgf23/αKlotho Signaling in Mice with Chronic Kidney Disease.
TL;DR: In this article, microRNA-based suppression of parathyroid FGF23/αKlotho axis activity may be a potential strategy to combat secondary hyperparathyroidism.
Journal ArticleDOI
Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish.
Isabel Reuter,Jana Jaeckels,Susanne Kneitz,Jochen Kuper,Klaus-Peter Lesch,Klaus-Peter Lesch,Christina Lillesaar +6 more
TL;DR: F fibroblast growth factor (Fgf)3 is identified as the main Fgf ligand controlling the ontogeny of serotonergic CSF-c cells and analysis of the developing hypothalamic transcriptome shows that the expression of fgf3 is upregulated upon fgF3 loss-of-function, suggesting activation of a self-compensatory mechanism.
Journal ArticleDOI
The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.
Carina Mucciolo Melo,Huawei Wang,Ken Fujimura,Jan Strnadel,Maria Cecília Zorél Meneghetti,Helena B. Nader,Richard L. Klemke,Maria Aparecida da Silva Pinhal +7 more
TL;DR: In this article, an HS-binding peptide was used to inhibit the proliferation of human endothelial umbilical cord cells (HUVEC) by modulation of FGF-2.
Journal ArticleDOI
Metabolic Messengers: fibroblast growth factor 1
TL;DR: Gasser et al. as discussed by the authors provide an overview of the known metabolic functions of endogenous fibroblast growth factor and discuss its therapeutic potential, distinguishing between peripherally or centrally administered FGF1.
Journal ArticleDOI
Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos
TL;DR: In this article, the effect of derazantinib (DZB) on blood vessel morphogenesis was investigated and compared to known specific FGFR and VEGFR inhibitors, revealing a potential dual role for DZB as a potent anti-angiogenic treatment.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
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