The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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A novel long noncoding RNA FAF inhibits apoptosis via upregulating FGF9 through PI3K/AKT signaling pathway in ischemia-hypoxia cardiomyocytes.
Hao-Jie Shi,Ming-Wei Wang,Jia-Teng Sun,Hao Wang,Ya-Fei Li,Bing-Rui Chen,Yi Fan,Si-Bo Wang,Zi-Mu Wang,Qi-Ming Wang,Lian-Sheng Wang +10 more
TL;DR: Mechanistically, FGF9 inhibited cardiomyocytes apoptosis through activating signaling tyrosine kinase FGFR2 via phosphoinositide 3‐kinase/protein kinase B signaling pathway and may serve as a treatment target for AMI.
Journal ArticleDOI
Quantifying the strength of heterointeractions among receptor tyrosine kinases from different subfamilies: Implications for cell signaling
TL;DR: Surprisingly, it is found that RTK heterodimerization and homodimerized strengths can be similar, underscoring the significance of RTKheterointeractions in signaling.
Journal ArticleDOI
Lineage-specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1-RUNX2 association in neural crest-derived osteoprogenitors
Fahad Kidwai,Byron W H Mui,Deepika Arora,Deepika Arora,Kulsum Iqbal,Madison Hockaday,Luis Fernandez de Castro Diaz,Natasha Cherman,Daniel Martin,Vamsee D. Myneni,Moaz Ahmad,Katarzyna Futrega,Sania Ali,Randall K. Merling,Dan S. Kaufman,Janice Lee,Pamela Gehron Robey +16 more
TL;DR: The results indicate that FGF1 influences RUNX2 levels, with concomitant changes in ERK1/2 signaling, and reveals new, potentially important pathways influencing these processes.
Journal ArticleDOI
Antihepatic Fibrosis Drugs in Clinical Trials
Yue-Cheng Guo,Lun-Gen Lu +1 more
TL;DR: It is extremely urgent to review the antihepatic fibrosis therapeutics for treatment of liver fibrosis in current clinical trials.
Journal ArticleDOI
Systematic Selection of Reference Genes for the Normalization of Circulating RNA Transcripts in Pregnant Women Based on RNA-Seq Data.
Stephen S.C. Chim,Karen K.W. Wong,Claire Yik-Lok Chung,Stephanie K.W. Lam,Jamie S. L. Kwok,Chit-Ying Lai,Yvonne K.Y. Cheng,Annie S. Y. Hui,Meng Meng,Oi-Ka Chan,Stephen Kwok-Wing Tsui,Keun-Young Lee,Ting-Fung Chan,Tak Yeung Leung +13 more
TL;DR: To overcome a lack of transcriptome, let alone whole-transcriptome, data from maternal blood, RNA-sequencing on blood samples from women presenting with preterm labor provided a starting point for systematically selecting reference gene candidates for normalizing the levels of circulating RNA transcripts in maternal blood.
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