The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
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Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure
Dae D Chung,Marisa R Pinson,Amanda H. Mahnke,Nihal A. Salem,Khang T. Le,Elizabeth A. Payne,Tenley E. Lehman,Susan T. Weintraub,Rajesh C. Miranda +8 more
TL;DR: This paper performed mass-spectrometry on extracellular vesicles (EVs) secreted by fetal murine cerebral cortical neural stem cells (NSCs), cultured ex-vivo as sex-specific neurosphere cultures, to identify overrepresented proteins and signaling pathways in EVs relative to parental NSCs in controls.
Journal ArticleDOI
Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation.
TL;DR: In this paper, the authors used sheep granulosa cells as a model and detected mRNA encoding 16 dual-specificity phosphatases (DUSP) in vivo and in vitro.
Journal ArticleDOI
Achieving resistance specificity in prostate cancer.
TL;DR: This review summarizes the current understanding of CaP and castration-recurrent CaP (CR-CaP) to earlier studies that characterized ADT and the molecular mechanisms that facilitate the transition from androgen-stimulated CaP to CR- CaP.
Journal ArticleDOI
iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel
TL;DR: In this paper , the cranial neural crest (CNC)-like cells (CNCLCs) were generated by modifying several steps of a previously established method for deriving NC-like cells from induced pluripotent stem cells (iPSCs).
Journal Article
The expression pattern of fibroblast growth factor 10 and its receptors during buffalo follicular development.
TL;DR: FGF10 and its receptors may be involved in the process of buffalo follicular development and oocyte maturation, laying a foundation for the further study of FGF signaling pathways in follicularDevelopment and oogenesis.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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