The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Biological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer.
Vera Loizzi,Vittoria Del Vecchio,Giulio Gargano,Maria De Liso,Anila Kardashi,Emanuele Naglieri,Leonardo Resta,Ettore Cicinelli,Gennaro Cormio +8 more
TL;DR: Bvacizumab is a monoclonal antibody that obstructs the binding of circulating vascular endothelial growth factor to its receptors and has been approved for the treatment of primary and recurrent ovarian cancer but also for many other solid tumors.
Journal ArticleDOI
Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation.
Yuli Li,Ruijia Wang,Xiaogang Xun,Jing Wang,Lisui Bao,Ramesha B. Thimmappa,Jun Ding,Jingwei Jiang,Liheng Zhang,Tianqi Li,Jia Lv,Chuang Mu,Xiaoli Hu,Lingling Zhang,Jing Liu,Yuqiang Li,Lijie Yao,Wenqian Jiao,Yangfan Wang,Shanshan Lian,Zelong Zhao,Yaoyao Zhan,Xiaoting Huang,Huan Liao,Jia Wang,Hongzhen Sun,Xue Mi,Yu Xia,Qiang Xing,Wei Lu,Anne Osbourn,Zunchun Zhou,Yaqing Chang,Zhenmin Bao,Shi Wang +34 more
TL;DR: The sequencing and analysis of the genome and extensive transcriptomes of the sea cucumber Apostichopus japonicus are reported, a species from a special echinoderm group with extraordinary potential for saponin synthesis, aestivation and organ regeneration.
Journal ArticleDOI
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process.
TL;DR: By activating AMPK, FGF21 can promote a healthy aging process and thus extend mammalian lifespan and the significance of the close connection between FGF 21 and AMPK signaling in the control of metabolic disorders and the aging process is discussed.
Journal ArticleDOI
Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration.
Nobuhiro Terao,Hideki Koizumi,Kentaro Kojima,Tetsuya Yamagishi,Yuji Yamamoto,Kengo Yoshii,Koji Kitazawa,Asako Hiraga,Munetoyo Toda,Shigeru Kinoshita,Chie Sotozono,Junji Hamuro +11 more
TL;DR: The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.
Journal ArticleDOI
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
TL;DR: Tubule-derived FGF23 may amplify myofibroblast activation in acute renal injury, and might provide a novel therapeutic target in renal fibrosis.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
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