The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.
TL;DR: A three-step molecular dynamics (MD)-based algorithm is developed and shows for the first time that appropriately designed sulfated NSGMs can be good structural mimetics of GAGs and the incorporation of a MD-based strategy at the NSGM library screening stage can identify promising mimetic of targeted GAG sequences.
Journal ArticleDOI
The neural crest cell hypothesis: no unified explanation for domestication.
TL;DR: The hypothesis entails that a reduction in neural crest cell proliferation and migration is a core genetic mechanism of early domestication, which implies that the genetic architecture of domestication is by necessity pleiotropic, with variants in genes affecting neural crest development and distribution causing multiple domestication traits.
Journal ArticleDOI
Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
Coralie Dessauges,Jan Mikelson,Maciej Dobrzyński,Marc-Antoine Jacques,Agne Frismantiene,Paolo Armando Gagliardi,Mustafa Khammash,Olivier Pertz +7 more
TL;DR: The RSK2-mediated feedback is thus important for the ability of the MAPK network to produce consistent ERK outputs and its perturbation can enhance the efficiency of MAPK inhibitors.
Journal ArticleDOI
Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels
Jingjing Liu,Gexiang Cai,Manxiang Li,Fan Shiqian,Boyang Yao,Ping Weidong,Zhifeng Huang,Hui Cai,Yongyue Dai,Liangxing Wang,Xiaoying Huang +10 more
TL;DR: Results demonstrate that FGF21 could potentially attenuate the pathogenic derangements of HPH by targeting PPARγ and inflammatory cytokines.
Journal ArticleDOI
DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas
Kathrin Schramm,Murat Iskar,Britta Statz,Natalie Jäger,Daniel Haag,Mikolaj Slabicki,Stefan M. Pfister,Marc Zapatka,Jan Gronych,David T.W. Jones,Peter Lichter +10 more
TL;DR: A large-scale gene knockdown approach using a pooled shRNA library in combination with next-generation sequencing suggests FGFR and PP2A signaling as potential new therapeutic targets for the treatment of DIPGs.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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