The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
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Glucocorticoids, genes and brain function
TL;DR: A review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain this article.
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Generalized extracellular molecule sensor platform for programming cellular behavior
Leo Scheller,Tobias Strittmatter,David W Fuchs,Daniel Bojar,Martin Fussenegger,Martin Fussenegger +5 more
TL;DR: A universal approach to designing receptor scaffolds that enables antibody-specific molecular input to activate JAK/STAT, MAPK, PLCG or PI3K/Akt signaling rewired to transgene expression driven by synthetic promoters is described.
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Scarless wound healing: Transitioning from fetal research to regenerative healing.
Alessandra L. Moore,Alessandra L. Moore,Clement D. Marshall,Leandra A. Barnes,Matthew P. Murphy,Ryan C. Ransom,Michael T. Longaker +6 more
TL;DR: Through a review of the major experimental targets of fetal wound healing, it is hoped to encourage research in areas that may have a significant clinical impact and investigate therapies currently in clinical use to evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent.
Journal ArticleDOI
Physiological Actions of Fibroblast Growth Factor-23.
TL;DR: There is an emerging role of FGF23 as an auto-/paracrine regulator of alkaline phosphatase expression and mineralization in bone and a physiological suppressor of differentiation of hematopoietic stem cells into the erythroid lineage in the bone microenvironment.
Journal ArticleDOI
Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression.
Dhruv Kumar,Jacob New,Vikalp Vishwakarma,Radhika Joshi,Jonathan Enders,Fangchen Lin,Sumana Dasari,Wade R. Gutierrez,George Leef,Sivapriya Ponnurangam,Hemantkumar Chavan,Lydia Ganaden,Mackenzie M. Thornton,Hongying Dai,Ossama Tawfik,Jeffrey Straub,Yelizaveta Shnayder,Kiran Kakarala,Terance T. Tsue,Douglas A. Girod,Bennett Van Houten,Shrikant Anant,Partha Krishnamurthy,Sufi M. Thomas +23 more
TL;DR: It is demonstrated that CAF-secreted HGF increases extracellular lactate levels in HNSCC via upregulation of glycolysis and contributes to metabolic symbiosis and a targetable therapeutic axis involving c-Met and FGFR.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
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