The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
More filters
Journal ArticleDOI
Tumor angiogenesis: causes, consequences, challenges and opportunities.
TL;DR: The current understanding of cellular and molecular mechanisms involved in tumor angiogenesis is summarized and challenges and opportunities associated with vascular targeting are discussed.
Journal ArticleDOI
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.
Arun J. Sanyal,Edgar D. Charles,Brent A. Neuschwander-Tetri,Rohit Loomba,Stephen A. Harrison,Manal F. Abdelmalek,Eric Lawitz,Dina Halegoua-DeMarzio,Sudeep Kundu,Stephanie Noviello,Yi Luo,Rose C. Christian +11 more
TL;DR: Treatment with subcutaneously administered pegbelfermin for 16 weeks was generally well tolerated and significantly reduced hepatic fat fraction in patients with non-alcoholic steatohepatitis, and the full planned sample size was not needed.
Journal ArticleDOI
Fibroblast growth factor signaling in skeletal development and disease
TL;DR: Progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis is examined, and the mechanisms by which mutations in FGF signalling molecules cause skeletal malformations in humans are explored.
Journal ArticleDOI
The molecular basis of endothelial cell plasticity
TL;DR: The endothelium is capable of remarkable plasticity in the embryo and in the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input that leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases.
Journal ArticleDOI
Classifying the evolutionary and ecological features of neoplasms
Carlo C. Maley,Athena Aktipis,Trevor A. Graham,Andrea Sottoriva,Amy M. Boddy,Michalina Janiszewska,Ariosto S. Silva,Marco Gerlinger,Yinyin Yuan,Kenneth J. Pienta,Karen S. Anderson,Robert A. Gatenby,Charles Swanton,David Posada,Chung I. Wu,Joshua D. Schiffman,E. Shelley Hwang,Kornelia Polyak,Alexander R. A. Anderson,Joel S. Brown,Mel Greaves,Darryl Shibata +21 more
TL;DR: A framework for classifying tumours is proposed that holds promise for enabling clinicians to personalize optimal interventions based on the evolvability of the patient's tumour, and the Evo- and Eco-indices provide a common lexicon for communicating about how neoplasms change in response to interventions.
References
More filters
Journal ArticleDOI
Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons.
Hans-Georg König,Beau J. Fenner,Jennifer C. Byrne,Robert Schwamborn,Tytus Bernas,Caroline A. Jefferies,Jochen H. M. Prehn +6 more
TL;DR: The results imply that FHF1 negatively regulates the constitutive NF-&kgr;B activity in neurons, and Fhf1 gene silencing strongly activated neurons and increased neurite lengths, branching patterns and spine counts in mature cortical neurons.
Journal ArticleDOI
The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes
Shereen Ezzat,Lei Zheng,Jose C. Florez,Norbert Stefan,Thomas Mayr,Maw Maw Hliang,Kathleen A. Jablonski,Maegan Harden,Alena Stančáková,Markku Laakso,Hans-Ulrich Häring,Axel Ullrich,Sylvia L. Asa +12 more
TL;DR: It is shown in humans that the FGFR4-R388 allele enhances islet function and may protect against type 2 diabetes, and these data support a common genetic link underlying cancer and hyperinsulinemia.
Journal ArticleDOI
Genetic Variation in FGF20 Modulates Hippocampal Biology
Herve Lemaitre,Venkata S. Mattay,Fabio Sambataro,Beth A. Verchinski,Richard E. Straub,Joseph H. Callicott,Raja Kittappa,Thomas M. Hyde,Barbara K. Lipska,Joel E. Kleinman,Ronald D.G. McKay,Daniel R. Weinberger +11 more
TL;DR: The effect of single-nucleotide polymorphisms (SNPs) in the fibroblast growth factor 20 gene (FGF20) associated with risk for Parkinson's disease on brain structure and function was explored in a large sample of healthy young-adult human subjects and also in elderly subjects to look at the interaction between genetic variations and age as mentioned in this paper.
Journal ArticleDOI
Lack of keratinocyte growth factor retards angiogenesis in cutaneous wounds
TL;DR: It is suggested that KGF may play an important role in the regulation of VEGF gene expression and angiogenesis during wound healing and real-time reverse transcription—polymerase chain reaction was used to measure vascular endothelial growth factor mRNA levels.
Related Papers (5)
Fibroblast growth factor signalling: from development to cancer
Nicholas C. Turner,Richard Grose +1 more