The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
TL;DR: This work hypothesized that one or both would be important downstream mediators of FGF20‐FGFR1 signaling for HC differentiation and implicated MAPK and PI3K pathways in HC and SC development.
Journal ArticleDOI
Cancer cachexia: lessons from Drosophila
TL;DR: Drosophila is emerging as a powerful model in which to identify tumor-derived factors that influence systemic metabolism and tissue wasting, suggesting that cachexia is more than one disease and that fly models can help identify these differences.
Journal ArticleDOI
Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma.
TL;DR: In this article, the authors performed an integrated analysis of DNA methylation and gene expression datasets to provide better mechanistic and molecular insights into Pancreatic cancers, especially PDAC, and gave a consensus of five cluster solution with relevant pathways like MAPK, MET.
Journal ArticleDOI
Overexpression of glycosyltransferase 8 domain containing 2 confers ovarian cancer to CDDP resistance by activating FGFR/PI3K signalling axis.
Shuting Huang,Suiying Liang,Suiying Liang,Suiying Liang,Guandi Chen,Guandi Chen,Guandi Chen,Jing Chen,Jing Chen,Jing Chen,Keli You,Keli You,Keli You,Haiyan Ye,Haiyan Ye,Haiyan Ye,Zhigang Li,Zhigang Li,Zhigang Li,Shanyang He,Shanyang He,Shanyang He +21 more
TL;DR: In this article, the expression of Glycosyltransferase 8 domain containing 2 (GLT8D2) was significantly upregulated in ovarian cancer samples with CDDP (Cis-dichlorodiammine-platinum) resistance.
Posted ContentDOI
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Finn Hawkins,Finn Hawkins,Shingo Suzuki,Mary Lou Beermann,Cristina Barillà,Ruobing Wang,Carlos Villacorta-Martin,Andrew Berical,Andrew Berical,Jyh-Chang Jean,Jake Le Suer,Jake Le Suer,Chantelle Simone-Roach,Yang Tang,Thorsten M. Schlaeger,Thorsten M. Schlaeger,Ana M. Crane,Sarah X.L. Huang,Scott H. Randell,Andras Rab,Eric J. Sorscher,Amjad Horani,Steven L. Brody,Brian R. Davis,Darrell N. Kotton,Darrell N. Kotton +25 more
TL;DR: The directed differentiation of human iPSCs into putative airway basal cells (“iBCs”) is reported, a population resembling the epithelial stem cell of lung airways, an approach which should facilitate disease modeling and future regenerative therapies for a variety of diseases affecting the lung airway diseases.
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