The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Growth Factors, Reactive Oxygen Species, and Metformin-Promoters of the Wound Healing Process in Burns?
Daniela Miricescu,Silviu Constantin Badoiu,Iulia-Ioana Stanescu-Spinu,Alexandra Totan,Constantin Ştefani,Maria Greabu +5 more
TL;DR: In this paper, the authors present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries and present the main aim of this review is to present the role of growth factor, reactiveoxygen species and met formin in healing and regeneration.
Journal ArticleDOI
Insights into the molecular regulatory network of pathomechanisms in osteochondroma
TL;DR: An update on the recent progress in the interpretation of the underlying molecular mechanisms of osteochondroma is provided.
Journal ArticleDOI
FGF19 Is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits Lung Fibrosis in Mice
TL;DR: In this article , the authors investigated the effect of FGF19 on lung morphology, lung collagen content, fibrosis markers, and profibrotic mediator expression at mRNA and protein levels.
Journal ArticleDOI
Novel Therapeutic Targets in Liver Fibrosis.
TL;DR: In this article, the authors highlight the importance of clarifying the mechanism of liver fibrosis and searching for new treatments against it, and highlight discoveries of novel therapeutic targets, which may provide new insights into potential treatments for Liver fibrosis.
Journal ArticleDOI
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
Luigi Maddaluno,Corinne Urwyler,Theresa Rauschendorfer,Michael Meyer,Debora Stefanova,Roman Spörri,Mateusz S. Wietecha,Luca Ferrarese,Diana Stoycheva,Daniela Bender,Nick Li,Gerhard E. Strittmatter,Khondokar Nasirujjaman,Khondokar Nasirujjaman,Hans-Dietmar Beer,Peter Staeheli,Eberhard Hildt,Annette Oxenius,Sabine Werner +18 more
TL;DR: An unexpected antagonistic effect of FGFs on the interferon (IFN) signaling pathway is identified and the use of FGFR kinase inhibitors for the treatment of viral infections is suggested.
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