The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
More filters
Journal ArticleDOI
FGF signalling facilitates cervical cancer progression
TL;DR: In this article , the role of FGFR signaling in cervical cancer was investigated through bioinformatic analysis of cell line and patient data and through detailed expression profiling, manipulation of the FGFR axis, and downstream phenotypic analysis in cell lines (HeLa, SiHa, and CaSki).
Journal ArticleDOI
The Evolving Role of FGFR2 Inhibitors in Intrahepatic Cholangiocarcinoma: From Molecular Biology to Clinical Targeting.
Massimiliano Salati,Francesco Caputo,Cinzia Baldessari,Pietro Carotenuto,Marco Messina,Stefania Caramaschi,Massimo Dominici,Luca Reggiani Bonetti +7 more
TL;DR: In this paper, the authors extensively reviewed the current evidence on the biological rationale, as well as preclinical and clinical development of FGFR inhibitors in intrahepatic cholangiocarcinoma (iCCA).
Journal ArticleDOI
Effects of FGFR Tyrosine Kinase Inhibition in OLN-93 Oligodendrocytes.
Ranjithkumar Rajendran,Gregor Böttiger,Niklas Dentzien,Vinothkumar Rajendran,Bischand Sharifi,Süleyman Ergün,Christine Stadelmann,Srikanth Karnati,Martin Berghoff +8 more
TL;DR: In this paper, the authors showed that FGFR inhibition in oligodendrocytes can be achieved by application of tyrosine kinase inhibitors, such as dovitinib and AZD4547.
Journal ArticleDOI
Targeting fibroblast growth factor receptors to combat aggressive ependymoma
Daniela Lötsch,Dominik Kirchhofer,Bernhard Englinger,Bernhard Englinger,Bernhard Englinger,Li Jiang,Konstantin Okonechnikov,Daniel Senfter,Daniel Senfter,Anna Laemmerer,Lisa Gabler,Christine Pirker,Andrew M. Donson,Peter Bannauer,Pia Korbel,Carola Jaunecker,Jens-Martin Hübner,Lisa Mayr,Sibylle Madlener,Maria T. Schmook,Gerda Ricken,Kendra K Maaß,Michael Grusch,Klaus Holzmann,Bettina Grasl-Kraupp,Sabine Spiegl-Kreinecker,Jennifer Hsu,Christian Dorfer,Karl Rössler,Amedeo A. Azizi,Nicholas K. Foreman,Nicholas K. Foreman,Andreas Peyrl,Christine Haberler,Thomas Czech,Irene Slavc,Mariella G. Filbin,Mariella G. Filbin,Kristian W. Pajtler,Kristian W. Pajtler,Marcel Kool,Walter Berger,Johannes Gojo +42 more
TL;DR: In this paper, the authors investigated the potential of FGFR1/FGFR3 as a therapeutic target for EPN using transcriptomic data across 467 EPN tissues and found that FG1 and FGFR3 mRNA levels were enriched in ST-RELA showing the highest expression among EPN as well as other brain tumors.
Posted ContentDOI
Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment
TL;DR: Evidence is provided for the first time that FGFR1 plays an essential role in the proliferation of PCa CSCs at a molecular and cellular level, and suggests that TKI targeting of FGFR signaling may be a promising strategy for AR-independent CRPC.
References
More filters
Journal ArticleDOI
AKT/PKB signaling: navigating downstream.
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Related Papers (5)
Fibroblast growth factor signalling: from development to cancer
Nicholas C. Turner,Richard Grose +1 more