The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Tumor angiogenesis: causes, consequences, challenges and opportunities.
TL;DR: The current understanding of cellular and molecular mechanisms involved in tumor angiogenesis is summarized and challenges and opportunities associated with vascular targeting are discussed.
Journal ArticleDOI
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.
Arun J. Sanyal,Edgar D. Charles,Brent A. Neuschwander-Tetri,Rohit Loomba,Stephen A. Harrison,Manal F. Abdelmalek,Eric Lawitz,Dina Halegoua-DeMarzio,Sudeep Kundu,Stephanie Noviello,Yi Luo,Rose C. Christian +11 more
TL;DR: Treatment with subcutaneously administered pegbelfermin for 16 weeks was generally well tolerated and significantly reduced hepatic fat fraction in patients with non-alcoholic steatohepatitis, and the full planned sample size was not needed.
Journal ArticleDOI
Fibroblast growth factor signaling in skeletal development and disease
TL;DR: Progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis is examined, and the mechanisms by which mutations in FGF signalling molecules cause skeletal malformations in humans are explored.
Journal ArticleDOI
The molecular basis of endothelial cell plasticity
TL;DR: The endothelium is capable of remarkable plasticity in the embryo and in the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input that leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases.
Journal ArticleDOI
Classifying the evolutionary and ecological features of neoplasms
Carlo C. Maley,Athena Aktipis,Trevor A. Graham,Andrea Sottoriva,Amy M. Boddy,Michalina Janiszewska,Ariosto S. Silva,Marco Gerlinger,Yinyin Yuan,Kenneth J. Pienta,Karen S. Anderson,Robert A. Gatenby,Charles Swanton,David Posada,Chung I. Wu,Joshua D. Schiffman,E. Shelley Hwang,Kornelia Polyak,Alexander R. A. Anderson,Joel S. Brown,Mel Greaves,Darryl Shibata +21 more
TL;DR: A framework for classifying tumours is proposed that holds promise for enabling clinicians to personalize optimal interventions based on the evolvability of the patient's tumour, and the Evo- and Eco-indices provide a common lexicon for communicating about how neoplasms change in response to interventions.
References
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Journal ArticleDOI
FOXO1–FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma
Jinglan Liu,Miguel A. Guzman,Donna M Pezanowski,Dilipkumar M Patel,John E. Hauptman,Matthew Keisling,Steve J Hou,Peter Papenhausen,Judy Mae Pascasio,Hope H. Punnett,Gregory E. Halligan,Jean-Pierre de Chadarévian +11 more
TL;DR: The first report to identify a novel fusion partner FGFR1 for the known anchor gene FOXO1 in alveolar rhabdomyosarcoma is reported, suggesting formation and amplification of a chimerical FoxO1–FGFR1 gene.
Journal ArticleDOI
Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis
Gina M. DeStefano,Katherine A. Fantauzzo,Lynn Petukhova,Mazen Kurban,Marija Tadin-Strapps,Brynn Levy,Dorothy Warburton,Elizabeth T. Cirulli,Yujun Han,Xiaoyun Sun,Yufeng Shen,Maryam Shirazi,Vaidehi Jobanputra,Rodrigo Cepeda-Valdes,Julio C. Salas-Alanis,Angela M. Christiano +15 more
TL;DR: A role for FGF13 in hair follicle growth and in the hair cycle is suggested and a 389-kb interchromosomal insertion at an extragenic palindrome site at Xq27.1 that completely cosegregates with the disease is identified.
Journal ArticleDOI
FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice.
Anne-Sophie Armand,Claude Pariset,Iman Laziz,Thierry Launay,Frédéric Di Fiore,Bruno Della Gaspera,Daniel Birnbaum,Frédéric Charbonnier,Christophe Chanoine +8 more
TL;DR: It is found that the appearance of myotubes was accelerated during regeneration of the soleus of FGF6 (−/−) mice versus wild type mice, and a model accounting for a specific dose‐dependent effect of F GF6 in muscle regeneration is proposed.
Journal ArticleDOI
FGF1 nuclear translocation is required for both its neurotrophic activity and its p53-dependent apoptosis protection
Aida Rodríguez-Enfedaque,Sylvina Bouleau,Maryvonne Laurent,Yves Courtois,Bernard Mignotte,Jean-Luc Vayssière,Flore Renaud +6 more
TL;DR: It is presented evidences that FGF1 may act by a nuclear pathway to induce neuronal differentiation and to protect the cells from apoptosis whether cell death is induced by serum depletion or p53 activation.
Journal ArticleDOI
IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells
Marko Kornmann,Toshiyuki Ishiwata,Kei Matsuda,Martha E. Lopez,Kimi Fukahi,Goro Asano,Hans G. Beger,Murray Korc +7 more
TL;DR: The data indicate that FGFR-1 IIIc is expressed in human pancreatic cancer cells, promotes mitogenic signaling via the FRS2-MAPK pathway, and has the potential to enhance pancreatic ductal cell transformation.
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