The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TLDR
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.Abstract:
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs) Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer © 2015 Wiley Periodicals, Incread more
Citations
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Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles
Thomas Ravn Lassen,Jesper Just,Marie Vognstoft Hjortbak,Nichlas Riise Jespersen,Katrine Tang Stenz,Tingting Gu,Yan Yan,Junyi Su,Jakob Hansen,Rikke Bæk,Malene Jørgensen,Jens R. Nyengaard,Jens R. Nyengaard,Steen B. Kristiansen,Kim Ryun Drasbek,Jørgen Kjems,Hans Erik Bøtker +16 more
TL;DR: In this article, the authors studied the role of extracellular vesicles (EVs) released into the circulation after remote ischemic conditioning (RIC) and EV accumulation in injured myocardium.
Journal ArticleDOI
Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein.
Anh Ngoc Nguyen,Jung A. Song,Minh Tan Nguyen,Bich Hang Do,Grace G. Kwon,Sang Su Park,Jiwon Yoo,Jaepyeong Jang,Jonghwa Jin,Mark J. Osborn,Yeon Jin Jang,Thu Trang Thi Vu,Heung Bum Oh,Han Choe +13 more
TL;DR: The MBP tag is useful for efficient prokaryotic production and purification of bioactive hFGF21 and significantly enhanced the solubility of the protein in the culture condition at 37°C.
Journal ArticleDOI
FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles.
Maia Azubel,Stephen D. Carter,Jennifer Weiszmann,Jun Zhang,Grant J. Jensen,Yang Li,Roger D. Kornberg +6 more
TL;DR: The fibroblast growth factor FGF21 was labeled with molecularly defined gold nanoparticles (AuNPs), applied to human adipocytes, and imaged by cryo-electron tomography (cryo-ET) to visualize signaling coupled to endocytosis.
Journal ArticleDOI
FGF2-induced STAT3 activation regulates pathologic neovascularization.
Zhenyu Dong,Andrea Santeford,Norimitsu Ban,Tae Jun Lee,Craig P. Smith,David M. Ornitz,Rajendra S. Apte +6 more
TL;DR: The identification of FGF2 as a critical mediator in aberrant neovascularization provides a new opportunity for developing multi-target therapies in blinding eye diseases especially given the limitations of anti-VEGF monotherapy.
Journal ArticleDOI
RNA-seq reveals transcriptome changes in goats following myostatin gene knockout.
TL;DR: Substantial changes in genes involved in fatty acid metabolism and the biosynthesis of unsaturated fatty acids are found, suggesting that the expression levels of these genes may be directly regulated by M STN and that these genes are likely downstream targets of MSTN with potential roles in lipid metabolism in goats.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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