Journal ArticleDOI
The influence of diet on the gut microbiota.
TLDR
The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.About:
This article is published in Pharmacological Research.The article was published on 2013-03-01. It has received 789 citations till now. The article focuses on the topics: Gut flora & Population.read more
Citations
More filters
Journal ArticleDOI
Colonic bacterial composition in Parkinson's disease.
Ali Keshavarzian,Stefan J. Green,Phillip A. Engen,Robin M. Voigt,Ankur Naqib,Christopher B. Forsyth,Ece Mutlu,Kathleen M. Shannon +7 more
TL;DR: It is shown that Parkinson's disease (PD) patients have alpha‐synuclein aggregation in their colon with evidence of colonic inflammation, and dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and PD pathology.
Journal ArticleDOI
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Robert Caesar,Valentina Tremaroli,Petia Kovatcheva-Datchary,Patrice D. Cani,Fredrik Bäckhed,Fredrik Bäckhed +5 more
TL;DR: It is shown that mice fed lard for 11 weeks have increased Toll-like receptor activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition.
Journal ArticleDOI
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Dorna Davani-Davari,Manica Negahdaripour,Iman Karimzadeh,Mostafa Seifan,Milad Mohkam,Seyed Jalil Masoumi,Aydin Berenjian,Younes Ghasemi +7 more
TL;DR: Health benefits of prebiotics and their safety, as well as their production and storage advantages compared to probiotics, they seem to be fascinating candidates for promoting human health condition as a replacement or in association with probiotics.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Journal ArticleDOI
The Controversial Role of Human Gut Lachnospiraceae.
Mirco Vacca,Giuseppe Celano,Francesco Maria Calabrese,Piero Portincasa,Marco Gobbetti,Maria De Angelis +5 more
TL;DR: Changes in Lachnospiraceae abundances according to health and disease are discussed and how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology are analyzed.
References
More filters
Journal ArticleDOI
Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects
TL;DR: The results demonstrate that RS2 and RS4 show functional differences in their effect on human fecal microbiota composition, indicating that the chemical structure of RS determines its accessibility by groups of colonic bacteria.
Journal ArticleDOI
Intestinal floras of populations that have a high risk of colon cancer.
W. E. C. Moore,L. V. H. Moore +1 more
TL;DR: Fecal floras of polyp patients, Japanese-Hawaiians, North American Caucasians, rural native Japanese, and rural native Africans were compared, and total concentrations of Bacteroides species and, surprisingly, Bifidobacterium species were generally positively associated with increased risk of colon cancer.
Journal ArticleDOI
Fermentation of Fructooligosaccharides and Inulin by Bifidobacteria: a Comparative Study of Pure and Fecal Cultures
Maddalena Rossi,Claudio Corradini,Alberto Amaretti,Marcello Nicolini,Anna Pompei,Simona Zanoni,Diego Matteuzzi +6 more
TL;DR: It is observed that bifidobacteria grew by cross-feeding on mono- and oligosaccharides produced by primary inulin intestinal degraders, as evidenced by the high hydrolytic activity of fecal supernatants.
Journal ArticleDOI
A core human microbiome as viewed through 16S rRNA sequence clusters.
TL;DR: It is found that commonalities between samples based on taxonomy could sometimes belie variability at the sub-genus OTU level, and even OTUs present in nearly every subject, or that dominate in some samples, showed orders of magnitude variation in relative abundance emphasizing the highly variable nature across individuals.
Journal ArticleDOI
Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era.
TL;DR: The specialty of gastroenterology will be affected profoundly by the ability to modify the gastrointestinal microbiota through the rational deployment of antibiotics, probiotics, and prebiotics.
Related Papers (5)
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
Microbial ecology: Human gut microbes associated with obesity
QIIME allows analysis of high-throughput community sequencing data.
J. Gregory Caporaso,Justin Kuczynski,Jesse Stombaugh,Kyle Bittinger,Frederic D. Bushman,Elizabeth K. Costello,Noah Fierer,Antonio Gonzalez Peña,Julia K. Goodrich,Jeffrey I. Gordon,Gavin A. Huttley,Scott T. Kelley,Dan Knights,Jeremy E. Koenig,Ruth E. Ley,Catherine A. Lozupone,Daniel McDonald,Brian D. Muegge,Meg Pirrung,Jens Reeder,Joel Sevinsky,Peter J. Turnbaugh,William A. Walters,Jeremy Widmann,Tanya Yatsunenko,Jesse R. Zaneveld,Rob Knight,Rob Knight +27 more