Journal ArticleDOI
The influence of diet on the gut microbiota.
TLDR
The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.About:
This article is published in Pharmacological Research.The article was published on 2013-03-01. It has received 789 citations till now. The article focuses on the topics: Gut flora & Population.read more
Citations
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Journal ArticleDOI
Colonic bacterial composition in Parkinson's disease.
Ali Keshavarzian,Stefan J. Green,Phillip A. Engen,Robin M. Voigt,Ankur Naqib,Christopher B. Forsyth,Ece Mutlu,Kathleen M. Shannon +7 more
TL;DR: It is shown that Parkinson's disease (PD) patients have alpha‐synuclein aggregation in their colon with evidence of colonic inflammation, and dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and PD pathology.
Journal ArticleDOI
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Robert Caesar,Valentina Tremaroli,Petia Kovatcheva-Datchary,Patrice D. Cani,Fredrik Bäckhed,Fredrik Bäckhed +5 more
TL;DR: It is shown that mice fed lard for 11 weeks have increased Toll-like receptor activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition.
Journal ArticleDOI
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Dorna Davani-Davari,Manica Negahdaripour,Iman Karimzadeh,Mostafa Seifan,Milad Mohkam,Seyed Jalil Masoumi,Aydin Berenjian,Younes Ghasemi +7 more
TL;DR: Health benefits of prebiotics and their safety, as well as their production and storage advantages compared to probiotics, they seem to be fascinating candidates for promoting human health condition as a replacement or in association with probiotics.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Journal ArticleDOI
The Controversial Role of Human Gut Lachnospiraceae.
Mirco Vacca,Giuseppe Celano,Francesco Maria Calabrese,Piero Portincasa,Marco Gobbetti,Maria De Angelis +5 more
TL;DR: Changes in Lachnospiraceae abundances according to health and disease are discussed and how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology are analyzed.
References
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Journal ArticleDOI
Protein degradation by human intestinal bacteria.
TL;DR: The results demonstrate that the gut microflora could potentially play a major role in proteolysis in the human colon.
Journal ArticleDOI
Intestinal bacteria and ageing
TL;DR: Dietary supplements containing prebiotics, probiotics and a combination of both of these, synbiotics show promising results with these supplements, although further longer‐term investigations are required to substantiate their use in elderly healthcare fields.
Journal ArticleDOI
Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
Audrey M. Neyrinck,Sam Possemiers,Céline Druart,Tom Van de Wiele,Fabienne De Backer,Patrice D. Cani,Yvan Larondelle,Nathalie M. Delzenne +7 more
TL;DR: In this article, the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice was investigated.
Journal ArticleDOI
Absence of intestinal microbiota does not protect mice from diet-induced obesity.
Christine K. Fleissner,Nora Huebel,Mohamed Mostafa Abd El-Bary,Gunnar Loh,Susanne Klaus,Michael Blaut +5 more
TL;DR: The absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.
Journal ArticleDOI
A microbial world within us
TL;DR: An overview is presented of the most recent developments and applications of novel culture‐independent approaches that promise to unravel the mechanisms of GI tract functionality and subsequent possibilities to exploit specifically these mechanisms in order to improve gut health.
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