Journal ArticleDOI
The influence of diet on the gut microbiota.
TLDR
The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.About:
This article is published in Pharmacological Research.The article was published on 2013-03-01. It has received 789 citations till now. The article focuses on the topics: Gut flora & Population.read more
Citations
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Journal ArticleDOI
Colonic bacterial composition in Parkinson's disease.
Ali Keshavarzian,Stefan J. Green,Phillip A. Engen,Robin M. Voigt,Ankur Naqib,Christopher B. Forsyth,Ece Mutlu,Kathleen M. Shannon +7 more
TL;DR: It is shown that Parkinson's disease (PD) patients have alpha‐synuclein aggregation in their colon with evidence of colonic inflammation, and dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and PD pathology.
Journal ArticleDOI
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Robert Caesar,Valentina Tremaroli,Petia Kovatcheva-Datchary,Patrice D. Cani,Fredrik Bäckhed,Fredrik Bäckhed +5 more
TL;DR: It is shown that mice fed lard for 11 weeks have increased Toll-like receptor activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition.
Journal ArticleDOI
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Dorna Davani-Davari,Manica Negahdaripour,Iman Karimzadeh,Mostafa Seifan,Milad Mohkam,Seyed Jalil Masoumi,Aydin Berenjian,Younes Ghasemi +7 more
TL;DR: Health benefits of prebiotics and their safety, as well as their production and storage advantages compared to probiotics, they seem to be fascinating candidates for promoting human health condition as a replacement or in association with probiotics.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Journal ArticleDOI
The Controversial Role of Human Gut Lachnospiraceae.
Mirco Vacca,Giuseppe Celano,Francesco Maria Calabrese,Piero Portincasa,Marco Gobbetti,Maria De Angelis +5 more
TL;DR: Changes in Lachnospiraceae abundances according to health and disease are discussed and how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology are analyzed.
References
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Journal ArticleDOI
An investigation of the endogenous formation of apparent total N-nitroso compounds in conventional microflora and germ-free rats.
TL;DR: Comparison of results with those from GF rats showed that the ATNC in the stomach and large intestine of the CV animals were formed by microbial action, most probably involving bacterial nitrate-reductase activity.
Journal ArticleDOI
Using Probiotics in Gastrointestinal Disorders
TL;DR: Although sufficient evidence is not currently available to provide a clear guidance on the best probiotic for a particular clinical indication, key scientific concepts are now emerging and will provide practical information on the use of these products in clinical practice.
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Microbiology: Learning about who we are.
TL;DR: Microbial inhabitants outnumber the authors' body's own cells by about ten to one and are the subject of intensive research, which is beginning to elucidate their roles in health and disease.
Journal ArticleDOI
Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.
Jean M. Winter,Laura S. Nyskohus,Graeme P. Young,Ying Hu,Michael A. Conlon,Anthony R. Bird,David L. Topping,Richard K. Le Leu +7 more
TL;DR: The delivery of fermentable carbohydrate to the colon (as resistant starch) seems to switch from fermentation of protein to that of carbohydrate and a reduction in adduct formation, supporting previous observations that dietary resistant starch opposes the mutagenic effects of dietary red meat.
Journal ArticleDOI
Studies on Amine Production in the Human Colon: Enumeration of Amine forming Bacteria and Physiological Effects of Carbohydrate and pH
E. A. Smith,George T. Macfarlane +1 more
TL;DR: In this article, high levels of amines were present in large intestinal material taken from five persons who had died suddenly, and the authors found that trimethylamine and propylamine constituted about 70% of total amine production at all sample dilutions, indicating these substances were rapidly absorbed from the rectum.
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