Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
TL;DR: It is highlighted how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state which could function as cancer stem cells, and its effects on the immunobiology of carcinomas.
Journal ArticleDOI
Wnt signaling in cancer.
TL;DR: Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control are described.
Journal ArticleDOI
Cancer stem cells revisited
Eduard Batlle,Hans Clevers +1 more
TL;DR: New developments in the cancer stem cell field are discussed in relationship to changing insights into how normal stem cells maintain healthy tissues and the first successes of therapies based on the CSC concept are emerging.
Journal ArticleDOI
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
TL;DR: The latest revelations about Cdks, cyclins and CKIs are discussed with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
Journal ArticleDOI
Mechanisms of Hippo pathway regulation
TL;DR: This review focuses on recent developments in the understanding of the molecular actions of the core Hippo kinase cascade and discusses key open questions in the regulation and function of the Hippo pathway.
References
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Journal ArticleDOI
Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation
Alejandra Berenice Ochoa-Hernández,Alejandra Berenice Ochoa-Hernández,Moisés Ramos-Solano,Ivan D. Meza‐Canales,Beatriz García-Castro,Mónica Alejandra Rosales-Reynoso,Judith A Rosales-Aviña,Esperanza Barrera-Chairez,Pablo C Ortiz-Lazareno,Georgina Hernández-Flores,Alejandro Bravo-Cuellar,Luis Felipe Jave-Suárez,Patricio Barros-Núñez,Adriana Aguilar-Lemarroy +13 more
TL;DR: This is the first report evidencing quantitatively decreased WNT7A levels in leukemia-derived cells and that W NT7A restoration in T-lymphocytes inhibits cell proliferation, and support the possible function of WNT 7A as a tumor suppressor gene as well as a therapeutic tool.
Journal ArticleDOI
Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness.
Alessandra Ulivieri,Luca Lavra,Roberto Dominici,Laura Giacomelli,Ercole Brunetti,Laura Sciacca,Maria Trovato,Gaetano Barresi,Theodoros Foukakis,L Jia-Jing,Catharina Larsson,Armando Bartolazzi,Salvatore Sciacchitano +12 more
TL;DR: The data indicated that FZD‐1 is involved in growth of follicular tumours and may be considered as a novel marker of this type of tumour.