Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
TL;DR: It is highlighted how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state which could function as cancer stem cells, and its effects on the immunobiology of carcinomas.
Journal ArticleDOI
Wnt signaling in cancer.
TL;DR: Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control are described.
Journal ArticleDOI
Cancer stem cells revisited
Eduard Batlle,Hans Clevers +1 more
TL;DR: New developments in the cancer stem cell field are discussed in relationship to changing insights into how normal stem cells maintain healthy tissues and the first successes of therapies based on the CSC concept are emerging.
Journal ArticleDOI
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
TL;DR: The latest revelations about Cdks, cyclins and CKIs are discussed with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
Journal ArticleDOI
Mechanisms of Hippo pathway regulation
TL;DR: This review focuses on recent developments in the understanding of the molecular actions of the core Hippo kinase cascade and discusses key open questions in the regulation and function of the Hippo pathway.
References
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Journal ArticleDOI
Beta-catenin inhibits melanocyte migration but induces melanoma metastasis.
Stuart J. Gallagher,Stuart J. Gallagher,Stuart J. Gallagher,Florian Rambow,Florian Rambow,Florian Rambow,Mayuko Y. Kumasaka,Mayuko Y. Kumasaka,Mayuko Y. Kumasaka,Delphine Champeval,Delphine Champeval,Delphine Champeval,Alfonso Bellacosa,Véronique Delmas,Véronique Delmas,Véronique Delmas,Lionel Larue,Lionel Larue,Lionel Larue +18 more
TL;DR: It is found that, unlike its positive role in stimulating migration and invasion of carcinoma cells, β-catenin signalling decreased the migration of melanocytes and melanoma cell lines, causing a white belly-spot phenotype.
Journal ArticleDOI
Wnt5a Suppresses Epithelial Ovarian Cancer by Promoting Cellular Senescence
Benjamin G. Bitler,Jasmine P. Nicodemus,Hua Li,Qi Cai,Hong Wu,Xiang Hua,Tianyu Li,Michael J. Birrer,Andrew K. Godwin,Paul Cairns,Rugang Zhang +10 more
TL;DR: It is suggested that strategies to drive senescence in EOC cells by reconstituting Wnt5a signaling may offer an effective new strategy for EOC therapy.
Journal ArticleDOI
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis.
TL;DR: It is demonstrated that NC043 is a novel small molecule that inhibits canonical Wnt signaling downstream of β-catenin stability and may be a potential compound for treating colorectal cancer.
Journal ArticleDOI
KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer.
Ji Hee Lee,Sei Ryun Park,Kee-Oh Chay,Young-Woo Seo,Hyun Kook,Kyu Youn Ahn,Young Jin Kim,Kyung Keun Kim +7 more
TL;DR: The results indicate that KITENIN promotes adhesion and invasion of cancer cells in vitro and in vivo, and suggest that K ITENIN participates in the regulation of the tumor formation and metastasis by interacting with KAI1, a metastasis suppressor and antisense KITenIN strategy that can be used to inhibit metastasis in various cancers.