Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity.
TL;DR: This review summarized the novel regulators existed in BCSCs and their niches for BCSC heterogeneity which has been discovered in recent years, and discussed their regulation mechanisms and the latest corresponding cancer treatments, which will extend the understanding onBCSC heterogeneity and plasticity and provide better prognosis prediction and more efficient novel therapeutic strategies for breast cancer.
Journal ArticleDOI
Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1
Ramakrishna Vadde,Sridhar Radhakrishnan,Hewage Eranda Karunathilake Kurundu,Lavanya Reddivari,Jairam Vanamala,Jairam Vanamala +5 more
TL;DR: Results indicate that amla suppresses HCCSC proliferation and induces apoptosis independent of p53 status via potentially targeting Wnt/β-catenin signalling pathway, and is therefore a promising functional food for preventing colon cancer and might be a novel resource for the food industry.
Journal ArticleDOI
Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae.
Yanfang Sun,Michael Wink,Pan Wang,Hong-Fei Lu,Hongxin Zhao,Liu Hongtao,Shi-xian Wang,Yang Sun,Zongsuo Liang +8 more
TL;DR: These findings provide the first evidence regarding the full-scale bioactive components and antineoplastic properties of CCBSP and highlight the significance of C. cicadae as a potential antineopolastic agent.
Journal ArticleDOI
Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor.
Li Wang,Jing Yang,Ling-Mei Kong,Jun Deng,Zijun Xiong,Jian-Ping Huang,Jianying Luo,Yijun Yan,Yi-Kao Hu,Xiao-Nian Li,Yan Li,Yong Zhao,Sheng-Xiong Huang +12 more
TL;DR: Euphordraculoates A and B, featuring tigliane diterpenoids with two new carbon skeletons, were characterized as metabolites of Euphorbia dracunculoides and semisynthetic products, respectively, by spectroscopic analyses and X-ray crystallography.
Journal ArticleDOI
CXCL9 promotes the progression of diffuse large B-cell lymphoma through up-regulating β-catenin
TL;DR: The results showed that CXC chemokine ligand 9 was highly expressed in diffuse large B-cell lymphoma tissues and cell lines, which showed close association with patients' advanced clinical progression and shorter overall survival.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.