Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling
TL;DR: The results indicate that the activation of compensatory pathways can potentially cause up-regulation of EGFR/ErbB pathway genes (counteracting the inhibiting effect of lapatinib) via signaling cross-talk and are interesting as potential targets for designing novel anti-cancer therapeutics.
Journal ArticleDOI
Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells
Midori A. Arai,Naoki Ishikawa,Mitsuha Tanaka,Kenji Uemura,Noriko Sugimitsu,Akiko Suganami,Yutaka Tamura,Takashi Koyano,Thaworn Kowithayakorn,Masami Ishibashi +9 more
TL;DR: Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells was isolated by using Hes1-immobilized beads.
Journal ArticleDOI
The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
Felice Contaldi,Federico Capuano,Andrea Fulgione,Riccardo Aiese Cigliano,Walter Sanseverino,Domenico Iannelli,Chiara Medaglia,Rosanna Capparelli +7 more
TL;DR: The pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis- regulated also in this study, suggesting new directions for the study of neurological diseases.
Journal ArticleDOI
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Masataka Takenaka,Motonobu Saito,Reika Iwakawa,Nozomu Yanaihara,Misato Saito,Mamoru Kato,Hitoshi Ichikawa,Tatsuhiro Shibata,Jun Yokota,Aikou Okamoto,Takashi Kohno +10 more
TL;DR: Ovarian cancers, particularly of non-serous types, frequently carry gene aberrations that link to therapy using molecular targeting drugs, and non-Serous histological type tumors showed such actionable gene alterations frequently.
Journal ArticleDOI
Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer
Tsuyoshi Hata,Yukako Mokutani,Hidekazu Takahashi,Akira Inoue,Koji Munakata,Kazuya Nagata,Naotsugu Haraguchi,Junichi Nishimura,Taishi Hata,Chu Matsuda,Kohei Murata,Tsunekazu Mizushima,Yuichiro Doki,Masaki Mori,Hirofumi Yamamoto +14 more
TL;DR: It is suggested that miR-487b may suppress metastasis of CRC progression through inhibition of KRAS, and survival analysis indicated that high expression of miR -487b was associated with better prognosis.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.