Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Critical roles of Wnt5a–Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial–mesenchymal transition
Taiki Sakamoto,Shintaro Kawano,Ryota Matsubara,Yuichi Goto,Teppei Jinno,Yasuyuki Maruse,Naoki Kaneko,Yuma Hashiguchi,Taichi Hattori,Shoichi Tanaka,Ryoji Kitamura,Tamotsu Kiyoshima,Seiji Nakamura +12 more
TL;DR: Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following ΔNp63β-mediated EMT.
Journal ArticleDOI
Modulation of cancer cell signaling by long noncoding RNAs.
Seyed Ali Mirhosseini,Mohammad Sarfi,Sadra Samavarchi Tehrani,Mohammad Mirazakhani,Mahmood Maniati,Jafar Amani +5 more
TL;DR: This review summarizes some of the most important of lncRNAs and their effect on important signaling pathways, which participate in the progression of cancer growth through several mechanism including signaling pathways.
Journal ArticleDOI
β-arrestin1 promotes epithelial-mesenchymal transition via modulating GSK-3β/β-catenin pathway in prostate cancer cells.
Xiaolu Duan,Tao Zhang,Zhenzhen Kong,Xin Mai,Chuangxin Lan,Dong Chen,Yang Liu,Zhiwen Zeng,Chao Cai,Tuo Deng,Wenqi Wu,Guohua Zeng +11 more
TL;DR: The data revealed that β-arrestin1 could promote the migration and invasion of prostate cancer cells via initiating epithelial-mesenchymal transition (EMT) and GSK-3β/β-catenin signaling in prostate cancer, suggesting that assessment of β-Arrestin 1 may provide a potential therapeutic target for prostate cancer.
Journal ArticleDOI
Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics
TL;DR: The small-molecule inhibitors targeting various components of Wnt signaling pathways are reviewed and the progress from the discovery of lead compounds to highly potent inhibitors with significant therapeutic potential is reviewed.
Journal ArticleDOI
Genomic landscape of gastric cancer: molecular classification and potential targets
TL;DR: Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, RhoA-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.