Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
TL;DR: It is highlighted how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state which could function as cancer stem cells, and its effects on the immunobiology of carcinomas.
Journal ArticleDOI
Wnt signaling in cancer.
TL;DR: Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control are described.
Journal ArticleDOI
Cancer stem cells revisited
Eduard Batlle,Hans Clevers +1 more
TL;DR: New developments in the cancer stem cell field are discussed in relationship to changing insights into how normal stem cells maintain healthy tissues and the first successes of therapies based on the CSC concept are emerging.
Journal ArticleDOI
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
TL;DR: The latest revelations about Cdks, cyclins and CKIs are discussed with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
Journal ArticleDOI
Mechanisms of Hippo pathway regulation
TL;DR: This review focuses on recent developments in the understanding of the molecular actions of the core Hippo kinase cascade and discusses key open questions in the regulation and function of the Hippo pathway.
References
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Journal ArticleDOI
WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription
Shaoqiong Chen,Denis C. Guttridge,Zongbing You,Zhaochen Zhang,Andrew M. Fribley,Marty W. Mayo,Jan Kitajewski,Cun-Yu Wang +7 more
TL;DR: It is reported that cells expressing Wnt-1 were resistant to cancer therapy–mediated apoptosis and suggests that WNT-1 may exhibit its oncogenic potential through a mechanism of anti-apoptosis.
Journal Article
Sporadic Medulloblastomas Contain Oncogenic β-Catenin Mutations
TL;DR: Data suggest that activating mutations in the β- catenin gene may be involved in the development of a subset of medulloblastomas, and that the GSK-3 β gene does not appear to be a target for inactivation in this tumor.
Journal ArticleDOI
A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer
Theresa A. DiMeo,Kristen Anderson,Pushkar Phadke,Chang Feng,Charles M. Perou,Steven Naber,Charlotte Kuperwasser +6 more
TL;DR: It is found that inhibiting wnt signaling through LRP6 reduced the capacity of cancer cells to self-renew and seed tumors in vivo, and inhibition of wnt signaled resulted in the reexpression of breast epithelial differentiation markers and repression of EMT transcription factors SLUG and TWIST.
Journal ArticleDOI
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
TL;DR: Dysregulation of pleiotropic growth factors, receptors and their downstream signaling pathway components represent a central protumorigenic principle in human hepatocarcinogenesis and several specific strategies are currently under development, which may improve the systemic treatment of human HCCs.
Journal ArticleDOI
Differential transformation of mammary epithelial cells by Wnt genes.
G T Wong,B J Gavin,A P McMahon +2 more
TL;DR: The results demonstrate that the Wnt gene family can be divided into three groups depending on their ability to induce morphological transformation and altered growth characteristics of the C57MG mammary epithelial cell line.