Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome
TL;DR: The rate of APC recycling at the centrosome is enhanced by MT growth, suggesting a positive feedback to stimulate its role in MT growth.
Journal ArticleDOI
Upregulation of miR-3607 promotes lung adenocarcinoma proliferation by suppressing APC expression.
TL;DR: It is suggested miR-3607 contributes to lung cancer cell proliferation by inhibiting APC.
BookDOI
Signalling Pathways in Embryonic Development
TL;DR: Signalling pathways in embryonic development was discussed in the recent Frontiers research topic "Signaling pathways in embryogenesis" as discussed by the authors, which focused mainly on vertebrates and explored different aspects of this theme from cell communication to organ formation.
Journal ArticleDOI
Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.
TL;DR: Low Dicer expression contributes to epithelial ovarian cancer progression by elevating PDIA3 expression and could significantly relieve the proliferation- and migration-promoting effect mediated by Dicer depletion in vitro and in vivo.
Journal ArticleDOI
APC functions at the centrosome to stimulate microtubule growth.
TL;DR: It is shown that siRNA knockdown of full-length APC delayed both initial MT aster formation and MT elongation/regrowth, and this process is disrupted by cancer mutations.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.