Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer.
TL;DR: The various aspects of Frizzled7 signalling and function are discussed, and the implications these have for therapeutic targeting of FriZZled7 in cancer are discussed.
Journal ArticleDOI
CTNNB1-mutant colorectal carcinomas with immediate invasive growth: a model of interval cancers in Lynch syndrome
Aysel Ahadova,Aysel Ahadova,Aysel Ahadova,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Hendrik Bläker,Matthias Kloor,Matthias Kloor,Matthias Kloor +9 more
TL;DR: The results suggest that a distinct subgroup of CRCs in Lynch syndrome may in fact emerge from a non-polypous precursor, thus potentially explaining the phenomenon of interval cancers.
Journal ArticleDOI
Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence
Ilangovan Ramachandran,Vengatesh Ganapathy,E Gillies,Isabel Fonseca,Sripathi M. Sureban,Courtney W. Houchen,Antonio M.C. Reis,Lurdes Queimado +7 more
TL;DR: It is reported for the first time that downregulation of the Wnt inhibitory factor 1 (WIF1) is a widespread event in salivary gland carcinoma ex-pleomorphic adenoma (CaExPA), and a novel mechanism by which WIF1 regulates cancer stemness and senescence is demonstrated, which might have major implications in the field of cancer biology.
Journal ArticleDOI
Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy.
James A. McCubrey,Nicole Marie Davis,Stephen L. Abrams,Giuseppe Montalto,Melchiorre Cervello,Jörg Bäsecke,Massimo Libra,Ferdinando Nicoletti,Lucio Cocco,Alberto M. Martelli,Linda S. Steelman +10 more
TL;DR: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palerzo, Italy
Journal ArticleDOI
Evidence of cancer‐promoting roles for AMPK and related kinases
TL;DR: A growing number of studies suggest a duality of functions for AMPK that are either pro‐ or anti‐cancer, depending upon context, which would point to tumour‐protective roles in the context of metabolic stress.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.