Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells.
Sangyun Shin,Hee-Jung Im,Yeo-Jung Kwon,Dong-Jin Ye,Hyoung-Seok Baek,Donghak Kim,Hyung-Kyoon Choi,Young-Jin Chun +7 more
TL;DR: The results suggest that STS induces Wnt/β-catenin signaling and EMT by upregulating Twist1 and HIF-1α, and has profound implications on estrogen-mediated carcinogenesis in human cancer cells.
Journal ArticleDOI
YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer
Chen Chen,Dong-Rong Zhu,Hao Zhang,Chao Han,Gui-Min Xue,Tianyu Zhu,Jian-Guang Luo,Ling-Yi Kong +7 more
TL;DR: Physalin F (PF), a steroid derivative isolated from Physalis angulate, acts as an antagonist of Wnt/β-catenin signalling and inhibited Wnt- β-catanin signalling by accelerating the ubiquitination and degradation of β- catenin in a YAP-dependent manner and therefore PF could be a novel potential candidate for CRC therapy.
Journal ArticleDOI
DNA methylation of tumor suppressor protein-coding and non-coding genes in multiple myeloma.
Kwan Yeung Wong,Chor Sang Chim +1 more
TL;DR: Methylation of protein-coding tumor suppressor genes, especially, the latest genome-wide methylation studies in myeloma are summarized, followed by the latest findings of methylation of non-Coding tumor suppressionor miRNAs in myELoma.
Journal ArticleDOI
Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.
Jessica Chinison,Jose S. Aguilar,Alan Avalos,Ying Huang,Zhijun Wang,D. Joshua Cameron,Jijun Hao +6 more
TL;DR: It is shown that triptonide can effectively inhibit canonical Wnt/β- catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-Catenin.
Journal ArticleDOI
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors
TL;DR: The differential requirements in HSCs and LSCs identify T cf1 and Lef1 transcription factors as novel therapeutic targets in treating hematological malignancies, and inhibition of Tcf1/Lef1-regulated transcriptional programs may provide a therapeutic window to eliminate L SCs with minimal side effect on normal HSC functions.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.