Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Prognostic value of wingless-type proteins in non-small cell lung cancer patients: a meta-analysis
Jiajia Jin,Ping Zhan,Hong Qian,Xiaoxia Wang,Masaru Katoh,Kevin Phan,Jin-Haeng Chung,Tangfeng Lv,Yong Song +8 more
TL;DR: Overexpression of Wnt proteins, as well as Wnt1 or Wnt5a alone, was markedly associated with adverse OS in lung cancer patients, suggesting that Wnts may act as a prognostic marker among NSCLCs.
Dissertation
Vascular stem cell migration in response to Dkk3 in vascular diseases : the emergence of a novel chemokine-like protein
TL;DR: This chapter discusses the evolution on the knowledge of the arterial adventitia and the role of vascular progenitor cells in atherosclerosis, as well as materials and methods used in this study.
Journal ArticleDOI
Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos
Xiaozhi Rong,Yumei Zhou,Yunzhang Liu,Beibei Zhao,Bo Wang,Caixia Wang,Xiaoxia Gong,Peipei Tang,Ling Lu,Yun Li,Chengtian Zhao,Jianfeng Zhou +11 more
TL;DR: The selenoenzyme Gpx4 regulates Wnt signaling and hence zebrafish axis formation by preventing the binding of Tcf/Lefs to the promoters of Wnt target genes, independently of selenocysteine activation.
Journal ArticleDOI
Comparative mutational landscape analysis of patient-derived tumour xenografts
Mariana Brait,Evgeny Izumchenko,Luciane T. Kagohara,Samuel Long,Piotr T. Wysocki,Brian Faherty,Elana J. Fertig,Tin Oo Khor,Elizabeth Bruckheimer,Gilson Baia,D. Ciznadija,Ido Sloma,Ido Ben-Zvi,Keren Paz,David Sidransky +14 more
TL;DR: This large-scale direct comparison and validation of currently available mutation detection approaches is extremely relevant for the current scenario of precision medicine and will lead to informed choice of screening methodologies, especially in lower budget conditions or time frame limitations.
Journal ArticleDOI
Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.
TL;DR: It is demonstrated that Chiron99021-treated Apc mutant organoids were rendered susceptible to TSA-induced apoptosis, while wild-type cells were protected, suggesting that excessive Wnt signalling reduces the relative fitness of ApC mutant cells.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.